Results 221 to 230 of about 109,999 (379)
Recent progress of ferroptosis in cancers and drug discovery
Asian Journal of Pharmaceutical SciencesFerroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation. Ferroptosis is involved in a range of pathological processes, such as cancer.
Xiang Wang +9 more
doaj
Advanced Science, EarlyView.PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen +13 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang +7 more
wiley +1 more source
Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling [PDF]
, 2019 Jiao Wu +7 more
openalex +1 more source
Advanced Science, EarlyView.The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu +8 more
wiley +1 more source
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Cell, 2012 S. Dixon +11 more
semanticscholar +1 more source
Advanced Science, EarlyView.Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen +14 more
wiley +1 more source
Ferroptosis in cancer (Review)
Oncology LettersFerroptosis is a type of programmed cell death depending on iron and reactive oxygen species. This unique cell death process has attracted a great deal of attention in the field of cancer research over the past decade. Research on the association of ferroptosis signal pathways and cancer development indicated that targeting ferroptosis has great ...
Zeng, Liyi +4 more
openaire +2 more sources
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis [PDF]
, 2019 Yilong Zou +19 more
openalex +1 more source
Advanced Science, EarlyView.The fabrication of ORL@Cu‐MOF and the mechanism of synergistic therapy by cuproptosis, reprogram fatty acid metabolism and anti‐PD‐1. Abstract Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates.
Zi‐Zhan Li +11 more
wiley +1 more source