Results 221 to 230 of about 147,915 (338)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Regorafenib promotes ferroptosis in acute myeloid leukemia by upregulating NOX4

Rong Mu, Xintong Pei, Nahua Xu, Baiping Liu, Lubin Liu, Hui Li, Qi Yao   +6 more
openalex   +1 more source

The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway

, 2023
Peng Lü, Xiaopei Li, Ben Li, Xiangyü Li, Chufan Wang, Zhaoyang Liu, Yumeng Ji, Xufeng Wang, Ziang Wen, Jidan Fan, Chenlong Yi, Meijuan Song, Xiaowei Wang   +12 more
openalex   +1 more source

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Ferroptosis as a Potential Mechanism in the Pathophysiology of Obstructive Sleep Apnea Syndrome. [PDF]

Nat Sci Sleep
Zeng X, Zhang N.
europepmc   +1 more source

Sesamin alleviates drug-induced hepatotoxicity via autophagy enhancement and ferroptosis inhibition

Jingyi Ren, Ziyi Wang, Yadong Zhang, Huan-Ting Pei, Rui Wen, Zhenao Zhang, Siqi Zhu, Xiaoya Sun, Bowen Yin, Shenghe Li, Yuxia Ma   +10 more
openalex   +1 more source

MR imaging guided iron-based nanoenzyme for synergistic Ferroptosis−Starvation therapy in triple negative breast cancer

, 2021
Duo Wang, Weimin Fang, Cuiqing Huang, Zerong Chen, Tianqi Nie, Jinghao Wang, Liangping Luo, Zeyu Xiao   +7 more
openalex   +1 more source

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

Advanced Science, EarlyView.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang, Jianming Yan, Tongxin Yu, Zichuan An, Kaikai Lv, Chenyu Xue, Hongyang Yu, Na Dong, Anshan Shan   +8 more
wiley   +1 more source

Ferroptosis in Adipose Tissue: A Double-Edged Sword Between Obesity Therapy and Stem Cell Risk. [PDF]

MedComm (2020)
Zayed M, Jeong BH.
europepmc   +1 more source

Exploring the Therapeutic Potential of MIR ‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies [PDF]

Feng Ma, Lexin Wang, Hao Chi, Xinyi Li, Yaoqin Xu, Kexin Chen, Jingheng Zhou, Runqin Yang, Jie Liu, Ke Xu, Xiaoling Yang   +10 more
openalex   +1 more source