Results 221 to 230 of about 99,374 (381)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy

Advanced Science, EarlyView.
Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li, Yuanjin Zhao   +3 more
wiley   +1 more source

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

, 2018
Ron Shah, Mikhail S. Shchepinov, Derek A. Pratt   +2 more
openalex   +1 more source

A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis [PDF]

, 2019
David Devos, Caroline Moreau, Maéva Kyheng, Guillaume Garçon, Anne‐Sophie Rolland, Hélène Blasco, Patrick Gelé, Timothée Lenglet, Charlotte Veyrat‐Durebex, Philippe Corcia, Mary Dutheil, Peter Bede, Andreas Jeromin, Patrick Oeckl, Markus Otto, Vincent Meininger, Véronique Danel-Brunaud, Jean-Christophe Devedjian, James A. Duce, Pierre Pradat   +19 more
openalex   +1 more source

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib [PDF]

, 2020
Xiang Song, Xinzhao Wang, Zhaoyun Liu, Zhiyong Yu   +3 more
openalex   +1 more source

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.

Nature Chemical Biology, 2017
S. Doll, B. Proneth, Y. Tyurina, Elena Panzilius, Sho Kobayashi, Irina Ingold, M. Irmler, J. Beckers, M. Aichler, A. Walch, H. Prokisch, D. Trümbach, G. Mao, F. Qu, H. Bayır, J. Füllekrug, C. Scheel, W. Wurst, Joel A. Schick, V. Kagan, J. Angeli, M. Conrad   +21 more
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Exogenous dihomo-γ-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells

Translational Oncology
Ferroptosis is a novel type of programmed cell death caused by excessive iron-dependent lipid peroxidation. According to various studies, there may be a link between ferroptosis and lipid metabolism.
Xiandong Jiang, Yingying Huang, Xiaoying Hong, Wei Wu, Yanfeng Lin, Liping Lin, Yan Xue, Donghong Lin   +7 more
doaj