Results 251 to 260 of about 147,915 (338)

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review). [PDF]

Int J Oncol
Zou R, Dai Y, Yang S, Hu H, Li F, Liu F.
europepmc   +1 more source

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells. [PDF]

Nat Commun
Son SW, Lee HJ, Kang N, Bae S, Cho E, Kwon H, Yoon DY, Lee C, Lee S, Son MK, Chae J, Kim S, Oh SJ, Sim Y, Lee KM, Yee C, Woo SR, Jeong YJ, Choi HJ, Kwak JY, Lee EW, Park J, Kwak SG, Chang YC, Kim TW, Song KH.   +25 more
europepmc   +1 more source

HJURP inhibits sensitivity to ferroptosis inducers in prostate cancer cells by enhancing the peroxidase activity of PRDX1

Wenjie Lai, Weian Zhu, Jianjie Wu, Jiongduan Huang, Xiaojuan Li, Yun Luo, Yu Wang, Hengda Zeng, Mingqiang Li, Xiaofu Qiu, Xingqiao Wen   +10 more
openalex   +1 more source

SLC11A1 protein as a key regulator of iron metabolism, ferroptosis mediator, and putative therapeutic target in nonalcoholic fatty liver disease: an integrated bioinformatics analysis [PDF]

Yang Wang, Bugao Zhou, Shanshan Li, Lin-Xin Zheng, Xiongfeng Huang, Huiyu Wang, Sili Li, Yuhan Lin, Yanhe Xu   +8 more
openalex   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Supplementary Figure S2 from The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma [PDF]

Linyong Shi, Hanning Chen, Kunxiang Chen, Chengzong Zhong, Chong Song, Yifeng Huang, Tong Wang, Lei Chen, Chiyang Li, Annie Huang, Qi Songtao, Hong Li, Yun-Tao Lu   +12 more
openalex   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

The "gut microbiota-ferroptosis axis": a hypothesis for osteoarthritis pathogenesis and therapeutic implications. [PDF]

Front Microbiol
Wang T, Xu Y, Zha H, Wu L.
europepmc   +1 more source

Ferroptosis in cancer (Review)

Liyi Zeng, Xiaohui Liu, Chengjie Geng, Xuejuan Gao, Langxia Liu   +4 more
openalex   +2 more sources