DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training
Advanced Science, EarlyView.DeepSecMS, a deep learning platform leveraging a Cys‐to‐Sec proxy training strategy, enhances the identification of known selenoproteins and holds promise for discovering novel candidates. This proxy approach overcomes limitations associated with the rarity of known selenoproteins and demonstrates broad applicability in studying other rare protein ...
Chenfang Si +5 more
wiley +1 more source
Integrative Analysis of Novel Ferroptosis-Related Genes Signatures as Prognostic Biomarkers in Ovarian Cancer. [PDF]
Cancer Rep (Hoboken)Cao L +5 more
europepmc +1 more source
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion [PDF]
, 2020 Yilong Zou +21 more
openalex +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
Ferroptosis: a key driver and therapeutic target in the pathogenesis of acute respiratory distress syndrome. [PDF]
Front ImmunolYao M +6 more
europepmc +1 more source
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
, 2019 Ishraq Alim +15 more
openalex +1 more source
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, EarlyView.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
Role of Ferroptosis in Alveolar Epithelial Cells in Acute Respiratory Distress Syndrome. [PDF]
J Inflamm ResSun B, Wang L, Zhang T.
europepmc +1 more source