Results 261 to 270 of about 72,927 (343)

Olive Leaf Extracts With High, Medium, or Low Bioactive Compounds Content Differentially Modulate Alzheimer's Disease via Redox Biology

Food Frontiers, EarlyView.
Olive leaf (OL) extracts were assessed for biomedical and phytochemical profiles. High‐OL extract was the most effective in inhibiting AChE, COX‐2, and iron‐reducing activity. Low‐ and high‐OL extracts showed significant effects against Aβ and tau toxicity in vivo. All extracts modulated redox biology at different levels. Only high‐OL extract prevented
Jose M. Romero‐Marquez, María D. Navarro‐Hortal, Alfonso Varela‐López, Rubén Calderón‐Iglesias, Juan G. Puentes, Francesca Giampieri, Maurizio Battino, Cristina Sánchez‐González, Jianbo Xiao, Roberto García‐Ruiz, Sebastián Sánchez, Tamara Y. Forbes‐Hernández, José L. Quiles   +12 more
wiley   +1 more source

Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway. [PDF]

Acta Cir Bras
Lan F, Long C, Huang H, Xie Y, Shi W.
europepmc   +1 more source

Anthocyanin Extracts From 11 Superfruits Mitigate Oxidative Stress and Inflammatory Damage in HK‐2 Cells Induced by Cadmium Exposure

Food Frontiers, EarlyView.
ABSTRACT Cadmium (Cd) pollution has emerged as an escalating threat to human health, with its induced kidney toxicity being closely linked to oxidative stress and inflammation. In this study, we extracted and analyzed primary anthocyanins from 11 superfruits using UPLC‐Triple‐TOF/MS and evaluated their antioxidant capacity through DPPH, ABTS, FRAP, and
Jiaojiao Liang, Yunyi Chen, Manxi Wu, Jiebiao Chen, Cui Sun, Jinping Cao, Yue Wang, Chongde Sun   +7 more
wiley   +1 more source

Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway. [PDF]

Clin Exp Pharmacol Physiol
Hou Z, Liu Y, Wang Q, Li P.
europepmc   +1 more source

Ferroptosis: An emerging therapeutic opportunity for cancer

, 2020
Liyuan Wang, Xiaoguang Chen, Chunhong Yan   +2 more
openalex   +1 more source

Based on single-cell and transcriptome data, ferroptosis and the immunological landscape in osteosarcoma were discovered. [PDF]

Discov Oncol
Jiang Y, Song C, Yan J, Luo L, Gao S, Jiang F, Wei Z, Chen J, Liu Z, Ge J.   +9 more
europepmc   +1 more source

Fibroblasts and hiPS‐Derived Astrocytes From CoPAN Patients Showed Different Levels of Iron Overload Correlated With Senescent Phenotype

Glia, EarlyView.
CoPAN affects CoA biosynthesis and leads to iron dyshomeostasis. CoPAN d‐astrocytes show ferroptosis, iron accumulation, senescence, lipid peroxidation, mitochondrial damage and tubulin acetylation loss. Astrocytes recapitulate CoPAN disease. ABSTRACT COASY protein‐associated neurodegeneration (CoPAN) is a rare autosomal recessive disorder within the ...
Anna Cozzi, Paolo Santambrogio, Andrea Stefano Moro, Alessio Pelagatti, Alicia Rubio, Chiara Balestrucci, Ivano Di Meo, Valeria Tiranti, Sonia Levi   +8 more
wiley   +1 more source

Ferroptosis: a novel perspective on tumor immunotherapy. [PDF]

Front Immunol
Xu Y, Ge M, Xu Y, Yin K.
europepmc   +1 more source

Energy-stress-mediated AMPK activation inhibits ferroptosis

, 2020
Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra K. Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F. Westbrook, Gregory R. Steinberg, Daisuke Nakada, Brent R. Stockwell, Boyi Gan   +12 more
openalex   +2 more sources

Exosomes, autophagy, and cancer: A complex triad

International Journal of Cancer, EarlyView.
Abstract Cancer remains one of the leading causes of death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, the incidence of certain types of cancer persists, urging the identification of clinically relevant biomarkers and the development of novel therapeutic strategies to improve clinical outcomes and overcome treatment ...
María Guerra‐Andrés, Álvaro F. Fernández, Tania Fontanil   +2 more
wiley   +1 more source