Results 261 to 270 of about 147,915 (338)

A Mitochondrial DNA‐Releasing Photosensitizer Potentiates Innate Immunity for Tumor Eradication and Prevention

open access: yesAggregate, EarlyView.
A mitochondria‐targeted photosensitizer, MQ‐PPy, with strong reactive oxygen species generation and mtDNA‐releasing capability, has been developed for photo‐induced antitumor immunoactivation. Upon light irradiation, MQ‐PPy induces mitochondrial oxidative damage and activates the cGAS‐STING pathway, promoting immunogenic cell death and cytotoxic T‐cell
Yanhe An   +7 more
wiley   +1 more source

Mitochondria‐Targeted AIE Materials for Oxidative Stress‐Mediated Cancer Therapy and Beyond

open access: yesAggregate, EarlyView.
This review summarizes recent advances in mitochondria‐targeted AIE materials that enable controllable oxidative stress for cancer therapy and beyond. It highlights the potential of such exogenous oxidative stress in innovative therapeutic applications and biological regulation, while also outlining key limitations and future perspectives.
Na Hao   +9 more
wiley   +1 more source

Aggregation‐Enhanced Asymmetric Heptamethine Cyanine Nanoplatform for Imaging‐Guided Synergistic Phototherapy and Ferroptosis

open access: yesAggregate, EarlyView.
An asymmetric heptamethine cyanine photosensitizer, Cyp‐TPE, is designed to break molecular symmetry and form ordered nanoaggregates, resulting in ultrahigh ROS generation and synergistic photothermal/photodynamic activity. It further triggers ferroptosis and lysosomal dysfunction, providing a potent aggregate‐based theranostic platform for imaging ...
Mengyuan Cui   +6 more
wiley   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan   +5 more
wiley   +1 more source

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