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Ferroptosis and Cancer Immunotherapy
Current Molecular Medicine, 2023Abstract: Traditional treatment strategies for cancer are unsatisfactory. As a nonapoptotic cell death process and owning to the characteristics of iron-dependent lipid peroxide accumulation, ferroptosis has become a new target of tumor treatment. Numerous studies have proved that ferroptosis could enhance the immunogenicity of cancer and interact ...
Jumei, Yin +6 more
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Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer
Advancement of scienceColorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis.
Zhou Yang +17 more
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Journal of Leukocyte Biology
Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Monitoring autophagy-dependent ferroptosis
2021Ferroptosis is an iron-dependent form of regulated cell death, driven by the accumulation of lipid peroxidation. Autophagy is a lysosome-dependent degradation process that can be used to remove and recover intracellular components, such as dysfunctional proteins and damaged organelles.
Jingbo, Li, Rui, Kang, Daolin, Tang
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Broadening horizons: the role of ferroptosis in cancer
Nature Reviews Clinical Oncology, 2021Xin Chen, R. Kang, G. Kroemer, D. Tang
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Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches
Cardiovascular Drugs and TherapyCardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for targeting ferroptosis to prevent and treat CVDs.A ...
Xianpeng, Zhou +9 more
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Ferroptosis and kidney diseases
International Urology and Nephrology, 2019Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis recently has been shown to have implications in diverse kidney diseases, such as acute kidney injury, polycystic kidney disease and renal cell carcinoma.
Shumei, Tang, Xiangcheng, Xiao
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Ferroptosis: when metabolism meets cell death.
Physiological ReviewsWe present here a comprehensive update on recent advancements in the field of ferroptosis, with a particular emphasis on its metabolic underpinnings and physiological impacts.
Jiashuo Zheng 郑嘉烁, Marcus Conrad
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Ferroptosis in mitochondrial cardiomyopathy
Trends in Cell BiologyFerroptosis is a form of necrotic cell death characterized by iron-dependent lipid peroxidation culminating in membrane rupture. Accumulating evidence links ferroptosis to multiple cardiac diseases and identifies mitochondria as important regulators of ferroptosis.
Ahola, S., Langer, T.
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