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PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis. [PDF]
Sci RepWang P +7 more
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, 2019 Ferroptosis is a newly identified form of cell death that depends on intracellular iron accumulation and lipid peroxidation. The tumor suppressor p53 is recently demonstrated either positively or negatively regulate ferroptosis, beyond its well-known effects on apoptosis and other non-apoptotic cell death including necroptosis and autophagy.
Shun Jiang, Yangchun Xie
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Journal of Leukocyte Biology
Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Ferroptosis: Concepts and Definitions
2021Ferroptosis is a newly discovered form of cell death that is rapidly becoming associated to a variety of diseases and explaining their pathological mechanisms. This book addresses new emerging topics in the field of ferroptosis, with special attention to diseases more recently explained through ferroptotic mechanisms, including infectious diseases and ...
Hamed Alborzinia, Andrés F. Flórez
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Broadening horizons: the role of ferroptosis in cancer
Nature Reviews Clinical Oncology, 2021Xin Chen, R. Kang, G. Kroemer, D. Tang
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Therapeutic exploitation of ferroptosis
Biochemical Society TransactionsPathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic regulation restrains peroxidation of phospholipids within cellular membranes, thereby impeding ...
Magali Walravens +2 more
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The Journal of Biochemistry
Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent phospholipid peroxidation and is closely related to various diseases. System Xc−, a cystine/glutamate antiporter, and glutathione peroxidase 4 (GPX4) are key molecules in ferroptosis.
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Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent phospholipid peroxidation and is closely related to various diseases. System Xc−, a cystine/glutamate antiporter, and glutathione peroxidase 4 (GPX4) are key molecules in ferroptosis.
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2019
Cell death is indispensable for the maintenance of organic homeostasis and embryonic development under physical circumstances. Ferroptosis is a newly discovered type of cell death by Stockwell research group in 2012. It is distinct from other cell death modalities including apoptosis, necroptosis, autophagy, and pyroptosis at morphological, genetic ...
Xiao-Yuan Mao, Xiao-Yuan Mao
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Cell death is indispensable for the maintenance of organic homeostasis and embryonic development under physical circumstances. Ferroptosis is a newly discovered type of cell death by Stockwell research group in 2012. It is distinct from other cell death modalities including apoptosis, necroptosis, autophagy, and pyroptosis at morphological, genetic ...
Xiao-Yuan Mao, Xiao-Yuan Mao
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2019
Glutathione peroxidase 4 (Gpx4) is a monomeric glutathione peroxidase with a unique ability to reduce hydroperoxide in complex lipids. Gpx4 is vital for development, and its function is also indispensable for many cell types of adult animal. Ferroptosis is an iron-dependent oxidative cell death. In ferroptosis, a high load of hydroperoxides in membrane
Paulina Mozolewska, Qitao Ran
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Glutathione peroxidase 4 (Gpx4) is a monomeric glutathione peroxidase with a unique ability to reduce hydroperoxide in complex lipids. Gpx4 is vital for development, and its function is also indispensable for many cell types of adult animal. Ferroptosis is an iron-dependent oxidative cell death. In ferroptosis, a high load of hydroperoxides in membrane
Paulina Mozolewska, Qitao Ran
openaire +2 more sources