Results 81 to 90 of about 72,927 (343)
Mitochondrial regulation of ferroptosis
Journal of Cell Biology, 2021 Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid peroxidation. Mitochondria are double-membrane organelles that have essential roles in energy production, cellular metabolism, and cell death regulation. However, their role in ferroptosis has been unclear and somewhat controversial.
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Ferroptosis and Brain Injury [PDF]
Developmental Neuroscience, 2018 Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process.
Leslie Magtanong, Scott J. Dixon
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Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
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Ferroptosis triggers airway inflammation in asthma
Therapeutic Advances in Respiratory Disease, 2023 Ferroptosis is a regulatory cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress. Many signaling pathways such as iron metabolism, lipid metabolism, and amino acid metabolism precisely regulate
Minming Li +6 more
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Establishment and biological characterization of radioresistant colorectal cancer cell lines
FEBS Open Bio, EarlyView.Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu +10 more
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Modelling ferroptosis in IPEC-J2 cells: insights into iron-dependent cell death
Italian Journal of Animal ScienceFerroptosis, a form of regulated cell death characterised by iron accumulation and lipid peroxidation, plays a crucial role in various diseases. However, its mechanisms in livestock, particularly in pigs, remain unclear.
Ching-Hsuan Liu, Yuan-Yu Lin
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Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution
Frontiers in PharmacologyFerroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. Ferroptosis is currently proposed as one of the most promising means of combating tumor resistance.
Kodzo Prosper Adzavon +3 more
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The Link between Malaria and Ferroptosis - A Review [PDF]
, 2022 Ferroptosis is an iron-dependent cell death characterized by extensive lipids peroxidation, dysfunctional glutathione-dependent antioxidant enzyme system, and alterations in the morphology of the mitochondrial membrane.
Amos Alex, Amos Alvan, Samson B. Wayah
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New Insights into the Role of Ferroptosis in Cardiovascular Diseases [PDF]
, 2023 Cardiovascular diseases (CVDs) are the principal cause of disease burden and death worldwide. Ferroptosis is a new formof regulated cell deathmainly characterized by altered ironmetabolism, increased polyunsaturated fatty acid peroxidation by reactive ...
Anna Maria FRATTA PASINI +5 more
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FEBS Open Bio, EarlyView.SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel +13 more
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