Results 81 to 90 of about 109,999 (379)
The endocannabinoid, anandamide, induces cannabinoid receptor-independent cell death in renal proximal tubule cells [PDF]
, 2017 Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Methods:
Barrett, David A. +11 more
core +3 more sources
The role of microRNAs in ferroptosis
Frontiers in Molecular Biosciences, 2022 Ferroptosis is a newly discovered type of programmed cell death, which is closely related to the imbalance of iron metabolism and oxidative stress. Ferroptosis has become an important research topic in the fields of cardiomyopathy, tumors, neuronal injury disorders, and ischemia perfusion disorders.
Liqing Guo +3 more
openaire +3 more sources
Cell Death Discovery, 2023 Alcohol abuse is a significant cause of global morbidity and mortality, with alcoholic liver disease (ALD) being a common consequence. The pathogenesis of ALD involves various cellular processes, including oxidative stress, inflammation, and hepatic cell
Jiao Luo +10 more
doaj +1 more source
The interaction between ferroptosis and inflammatory signaling pathways
Cell Death and Disease, 2023 Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of
Yue Chen +4 more
semanticscholar +1 more source
Ferroptosis inhibitors: past, present and future
Frontiers in PharmacologyFerroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective ...
Lei Zhang +7 more
doaj +1 more source
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis
mBio, 2023 Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis.
Xi-Qiu Xu +9 more
doaj +1 more source
Regulatory mechanism of ferroptosis, a new mode of cell death [PDF]
, 2019 Ferroptosis is a newly discovered process of cell death that differs from apoptosis, autophagy, and pyroptosis. It is closely related to tumor formation, diseases that damage tissue, and neurodegenerative diseases.
Da Liu +5 more
openalex +3 more sources
Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine [PDF]
, 2016 Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy.
Blyth, Karen +6 more
core +1 more source
Ferroptosis in Cancer Progression
Cells, 2023 Ferroptosis is a newly discovered iron-dependent form of regulated cell death driven by phospholipid peroxidation and associated with processes including iron overload, lipid peroxidation, and dysfunction of cellular antioxidant systems. Ferroptosis is found to be closely related to many diseases, including cancer at every stage. Epithelial–mesenchymal
Rongyu Zhang +5 more
openaire +3 more sources
Ferroptosis triggers airway inflammation in asthma
Therapeutic Advances in Respiratory Disease, 2023 Ferroptosis is a regulatory cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress. Many signaling pathways such as iron metabolism, lipid metabolism, and amino acid metabolism precisely regulate
Minming Li +6 more
doaj +1 more source