Results 121 to 130 of about 967,634 (337)

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

Nature Communications, 2020
How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos ...
Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan   +8 more
doaj   +1 more source

Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes

Reproductive Biology and Endocrinology, 2020
Oocyte activation inefficiency is one of the reasons for female infertility and Ca2+ functions play a critical role in the regulation of oocyte activation.
Feng Wang, Ang Li, Tie-Gang Meng, Le-Yun Wang, Li-Juan Wang, Yi Hou, Heide Schatten, Qing-Yuan Sun, Xiang-Hong Ou   +8 more
doaj   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Initial experience of dedicated breast PET imaging of ER+ breast cancers using [F-18]fluoroestradiol. [PDF]

, 2019
Dedicated breast positron emission tomography (dbPET) is an emerging technology with high sensitivity and spatial resolution that enables detection of sub-centimeter lesions and depiction of intratumoral heterogeneity.
Chien, Amy J, Esserman, Laura J, Franc, Benjamin L, Hylton, Nola M, Joe, Bonnie N, Jones, Ella F, Li, Wen, Mukhtar, Rita A, Pampaloni, Miguel H, Ray, Kimberly M, Seo, Youngho   +10 more
core   +2 more sources

Long‐Term Active Rather than Passive Restoration Promotes Soil Organic Carbon Accumulation by Alleviating Microbial Nitrogen Limitation in an Extremely Degraded Alpine Grassland

Advanced Science, EarlyView.
Active restoration increases soil organic carbon stocks by reducing microbial nitrogen limitation. Nitrogen availability promotes particulate to mineral‐associated organic carbon conversion by reducing microbial carbon use efficiency. Passive restoration has no effect on soil organic carbon stocks.
Jinchao Gong, Feida Sun, Jingjing Wu, Shijie Zhou, Yue Xiu, Linlin Li, Tahmina Kausar, Zhouwen Ma, Jiqiong Zhou, Lin Liu, Yongxing Cui, Jordi Sardans, Josep Peñuelas, Ahmed Elrys, Ji Chen, Yanfu Bai   +15 more
wiley   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Pubertal low dose exposure to benzophenone-3 (BP-3) alters murine mammary stem cell functions

Ecotoxicology and Environmental Safety
Benzophenone-3 (BP-3) is an organic UV filter that is widely used in personal care products and has been indicated to have negative impacts on the environment and human health.
Hui Gao, Xintong Yang, Pengge Pan, Xueli Liu, Yan Ma, Yadan Chen, Yunxin Liu, Yaqi Sun, Sinan Cao, Yuan Tian, Yanzhou Yang   +10 more
doaj   +1 more source

Body Phenomenology, Somaesthetics and Nietzschean Themes in Medieval Art [PDF]

, 2014
Richard Shusterman suggested that Maurice Merleau-Ponty neglected “‘lived somaesthetic reflection,’ that is, concrete but representational and reflective body consciousness.” While unsure about this assessment of Merleau-Ponty, lived somaesthetic ...
Crippen, Matthew
core  

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source