Results 111 to 120 of about 955,198 (296)

Balancing Exploration and Exploitation Through a Sequential Hybrid of Roach Infestation and Mayfly Algorithms for Constrained Engineering Design Optimization

AI &Innovation, EarlyView.
ABSTRACT Maintaining an effective balance between exploration and exploitation is essential during optimization processes, from mathematical functions to more complex problems such as constrained engineering design optimization, particularly when addressing highly nonlinear issues with numerous local optima and strict feasibility requirements.
Enrique Lizárraga, Fevrier Valdez, Oscar Castillo, Patricia Melin   +3 more
wiley   +1 more source

Improving access to new technologies: An experiment with Kenyan input sellers

American Journal of Agricultural Economics, EarlyView.
Abstract Agrodealers play a critical role in rural economies, selling essential inputs for agricultural production, stocking new products, and providing farmers with technical advice. However, uncertainty can discourage them from stocking newer, less familiar products, limiting the availability of innovative technologies and leading to market failures ...
Sarah W. Kariuki, Francisca N. Muteti, Annemie Maertens, Michael Ndegwa, Hope Michelson, Mercy Mbugua, Jason Donovan   +6 more
wiley   +1 more source

Quercetin Attenuates Iron Overload-Induced Renal Injury via Activating Nrf2/xCT/GPX4 Signaling to Inhibit Ferroptosis

Life
Iron overload, a key driver of ferroptosis, results from excessive iron accumulation in tissues and contributes to organ injury, including renal dysfunction.
Xiaoyi Wang, Wenmi Li, Wenzheng Yuan, Ziyu Wei, Zixuan Yang, Zichun Zhang, Zhibin Sun, Guojie Ji, Huanhuan Hu   +8 more
doaj   +1 more source

Fertility Risk Assessment and Preservation in Male and Female Prepubertal and Adolescent Cancer Patients

, 2016
Cancer represents the second cause of death in prepubertal children and adolescents, although it is currently associated with an overall survival rate of 80%–85%.
Aargyris Siatelis, Charalampos Siristatidis, Argyris Siatelis, Nikolaos Zavras, Anna Koumarianou, Aanna Koumarianou   +5 more
core   +1 more source

The Made‐in‐Africa Evaluation framework: A decolonial approach to program evaluation

American Journal of Community Psychology, EarlyView.
Abstract The Made in Africa Evaluation (MAE) framework is a decolonial approach to program evaluation developed by African evaluators over the past 14 years. MAE may be appropriate to community psychologists who practice program evaluation or conduct research in Africa, but little is known about its implementation.
Takatso Sibanda, Robin Lin Miller
wiley   +1 more source

Paternal ribosome biogenesis dysfunction caused by cyclophosphamide-busulfan chemotherapy contributes to early embryonic developmental impairment in mice

Journal of Translational Medicine
Background Combined cyclophosphamide (CTX) and busulfan (BUS) chemotherapy, while effective against malignancies, poses significant risks to male reproductive health. This study systematically investigates the proteomic basis underlying CTX + BUS-induced
Xin Li, Zexin Bian, Xialu Liu, Liyun Cao, Peipei Liu, Hongying Xu, Yan Zhao, Jun Tan   +7 more
doaj   +1 more source

[Methods for fertility preservation]

, 2023
Methods for cryopreservation of sperms, eggs, embryos and gonadal tissue have been developed and are available at many centers that have programs for fertility preservation.
Rodriguez-Wallberg, K,
core  

Navigating Asparaginase Treatment for Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations on the Role of Multidisciplinary Care

American Journal of Hematology, EarlyView.
ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali, Grace Elsey, Kayla Fulginiti, Zanette Kanani‐Bradley, Holly R. Kubaney, Sandra Kurtin, Theresa Nguyen, Jennifer Turchina, Charlotte B. Wagner   +8 more
wiley   +1 more source

Metformin modulates the TXNIP-NLRP3-GSDMD pathway to improve diabetic bladder dysfunction

Scientific Reports
To validate the therapeutic efficacy of metformin on diabetic bladder dysfunction (DBD) and further elucidate whether the TXNIP-NLRP3-GSDMD axis serves as a target for metformin in ameliorating DBD. C57BL/6J mice were induced with diet-induced obesity by
Bincheng Huang, Jin Zhang, Haifu Tian, Shuai Ren, Keming Chen, Jiajin Feng, Shuzhe Fan, Yunshang Tuo, Xuehao Wang, Leyi Yu, Cunling Ma, Qingjie Peng, Xiaojiang Chen, Rui He, Guangyong Li   +14 more
doaj   +1 more source

A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy

Frontiers in Pharmacology
The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for ovarian cancer by modulating the tumor microenvironment.
Yizheng Zu, Yizheng Zu, Min Li, Min Li, Ruyue Li, Ruyue Li, Shaohan Ma, Shaohan Ma, Yu’e Yang, Yu’e Yang, Shun Zhang, Yuan Ma, Yuan Ma, Tiantian Wu, Chunfang Ha, Chunfang Ha   +15 more
doaj   +1 more source