Results 91 to 100 of about 1,000,776 (293)

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source

Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency

Stem Cell Research & Therapy
Background Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesicles (ADSC-EVs) show more safety ...
Yanquan Li, Feng Chen, Wei Zhao, Di Sun, Li Zhang, Rui Qiao, Qianhui Hu, Songmao Li, Boyuan Chen, Haixia Ding, Meiling Zhang, Qing Zhang, Fanghao Guo, Wen Li   +13 more
doaj   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Asthma and Infertility: A Prospective Case–Control Study on Pregnancy and Live Birth Rates in Women With Asthma Undergoing Assisted Reproduction

The Clinical Respiratory Journal
Background Previous studies have suggested a negative impact of asthma on fertility, and it has been hypothesized that the underlying inflammation is playing an important role.
Frida E. Lundberg, Amalie H. Sneckenborg, Hanna Nilsson, Kenny A. Rodriguez‐Wallberg   +3 more
doaj   +1 more source

Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines [PDF]

, 2017
Fertility preservation plays a central role in cancer care since an increasingly large number of cancer patients are surviving as a result of improvements in diagnostic and therapeutic strategies.
Hwang, KJ, Sanghoon Lee, Kim, T, Kyung Joo Hwang, Tak Kim, Seul Ki Kim, Kim, SH, Seok Hyun Kim, Lee, S, Kim, SK   +9 more
core   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo

Ecotoxicology and Environmental Safety
5-Fluorouracil (5-FU), a chemotherapeutic drug used to treat a variety of cancers, can enter the environment through different routes, causing serious public health and environmental concerns.
Wenzheng Yuan, Guojie Ji, Xiaowei Shi, Zhibin Sun, Chenyan Liu, Yangyang Yu, Wenmi Li, Xiaoyi Wang, Huanhuan Hu   +8 more
doaj   +1 more source

Mechanochemically Disordered Li2Ta2OCl10 Oxyhalide Unlocks Superionic Conductivity (>10 mS.cm−1)

Advanced Energy Materials, EarlyView.
This work presents a new crystalline oxyhalide, Li2Ta2OCl10, built from [Ta2OCl10]2− dimers. The disorder induced by ball‐milling drives the dramatic 5000‐fold increase in ionic conductivity to reach 11 mS.cm−1. The material shows promise as a solid electrolyte for batteries and opens new prospects for the discovery of new dimer‐based compounds ...
Clément Morel, Anshuman Chaupatnaik, Jie Liu, Mingxue Tang, Horyung Ji, Mouna Ben Yahia, Marie‐Liesse Doublet, Tatiana N. Kobernik, Dmitry A. Aksyonov, Artem M. Abakumov, Gwenaëlle Rousse, Jean‐Marie Tarascon   +11 more
wiley   +1 more source

Random -start versus conventional ovarian hyperstimul,ation for fertility preservation in female cancer patients: a systematic review and meta analysis

, 2023
Random -start versus conventional ovarian hyperstimul,ation for fertility preservation in female cancer patients: a systematic review and meta ...
Sönmezer, Murat, Ateş, Can, Atabekoğlu, Cem Somer, Sönmezer, Meltem, Demirel, Cem, Saçıntı, Koray Görkem, Şükür, Yavuz Emre   +6 more
core  

The legacy of sperm banking: how fertility monitoring and disposal of sperm are linked with views of cancer treatment [PDF]

, 2011
Background: sperm banking is recommended for all men before cancer treatment, which carries a risk of long-term gonadal damage. However, relatively few men take up the offer.
Arden-Close, Emily, C. Eiser, Eiser, C., Pacey, A.A., Pacey, A. A.; id_orcid, Morris, K., E. Arden-Close, K. Morris, A. A. Pacey, Arden-Close, E.   +9 more
core   +1 more source