Results 71 to 80 of about 37,352 (297)

[Fertility Preservation in Prepubertal und Pubertal Children and Adolescents]. [PDF]

, 2018
BACKGROUND Due to rising survival rates in cancer and autoimmune diseases fertility preservation before gonadotoxic therapies has become increasingly important. Although fertility can be significantly affected by gonadotoxic therapies, the possibility
Sabine Kliesch, Liebenthron, Jana, Kliesch, Sabine, Nicole Sänger, Thomas Klingebiel, Falk Ochsendorf, Michael von Wolff, Jarisch, Andrea, Jana Liebenthron, Ochsendorf, Falk, Andrea Jarisch, von Wolff, Michael, Sänger, Nicole, Klingebiel, Thomas   +13 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Freezing the Biological Clock: A Viable Fertility Preservation Option for Young Singaporean Women? [PDF]

, 2013
In March 2012, an article in The Straits Times entitled ‘Freezing eggs could reverse falling birth rate’ suggested that employing the latest oocyte cryopreservation techniques could both foster individual women’s reproductive autonomy and impact ...
Lee, Geok Ling, Blyth, E., Yee, Samantha, Blyth, Eric, Yee, S., Lee, G.L.   +5 more
core  

Fertility Risk Assessment and Preservation in Male and Female Prepubertal and Adolescent Cancer Patients [PDF]

, 2016
Cancer represents the second cause of death in prepubertal children and adolescents, although it is currently associated with an overall survival rate of 80%–85%.
Aargyris Siatelis, Charalampos Siristatidis, Argyris Siatelis, Nikolaos Zavras, Anna Koumarianou, Aanna Koumarianou   +5 more
core   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

A review of fertility preservation in women in Singapore from 2010 to 2019 [PDF]

Cancer cases in Singapore have increased nearly sevenfold from 12,072 in 1968–1972 to 84,002 in 2017–2021.1 Despite this, survival rates have improved due to early detection and advancements in treatment, resulting in a shift in focus to long-term ...
Jessie Wai Leng Phoon, Toon Wen Tang, Shu Ying Charissa Goh   +2 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Fertility preservation in women with malignant tumors and gonadotoxic treatments [PDF]

, 2012
Because of improved survival rates and recent advances in reproductive medicine, fertility preservation methods in women of reproductive age with malignant or autoimmune diseases have risen in ...
Dian, Darius, Darius Dian, von Wolff, Michael, Michael von Wolff   +3 more
core   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Study on the mechanism of black Chinese wolfberry (Lycium ruthenicum Murr.) polyphenols relieving male urogenital damage caused by benzophenone-3 based on network pharmacology

Guangxi Yike Daxue xuebao
Objective To investigate the effects of the polyphenols extracted from Lycium ruthenicum Murr. (L. ruthenicum) on male urogenital damage caused by benzophenone-3 (BP-3) and its mechanism.
SUN Jiahe, DIAO Hong, YANG Haixin, CHEN Xuying, WANG Haowen, GAO Yanrong, XU Haiming, LI Hongmei   +7 more
doaj   +1 more source