Results 81 to 90 of about 955,198 (296)

Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice

Toxics
Male infertility, as a globally significant reproductive health issue, remains idiopathic in over 40% of cases. Reproductive disorders in males induced by environmental pollutants, such as di(2-ethylhexyl) phthalate (DEHP), have garnered considerable ...
Zhen Zhang, Yitong Shang, Hong Yang, Liyang Ding, Yu Deng, Bo Xu, Xufeng Fu   +6 more
doaj   +1 more source

[Fertility Preservation in Prepubertal und Pubertal Children and Adolescents]. [PDF]

, 2018
BACKGROUND Due to rising survival rates in cancer and autoimmune diseases fertility preservation before gonadotoxic therapies has become increasingly important. Although fertility can be significantly affected by gonadotoxic therapies, the possibility
Sabine Kliesch, Liebenthron, Jana, Kliesch, Sabine, Nicole Sänger, Thomas Klingebiel, Falk Ochsendorf, Michael von Wolff, Jarisch, Andrea, Jana Liebenthron, Ochsendorf, Falk, Andrea Jarisch, von Wolff, Michael, Sänger, Nicole, Klingebiel, Thomas   +13 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

The Protective Effect and Molecular Mechanism of Tetrandrine on Male Reproductive Damage Caused by Silicon Dioxide

Toxics
The long-term inhalation of free silica dust causes silicosis—a prevalent occupational hazard—yet its systemic effect on male reproductive toxicity remains underexplored.
Hong-Mei Li, Xiao-Qi Zeng, Qing Chang, Yu-Xin Sheng, Ya-Jia Pu, Yi Wang, Bin Cheng, Hong-Hui Li, Jie Xuan, Ling Zhang, Hai-Ming Xu   +10 more
doaj   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency

Stem Cell Research & Therapy
Background Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesicles (ADSC-EVs) show more safety ...
Yanquan Li, Feng Chen, Wei Zhao, Di Sun, Li Zhang, Rui Qiao, Qianhui Hu, Songmao Li, Boyuan Chen, Haixia Ding, Meiling Zhang, Qing Zhang, Fanghao Guo, Wen Li   +13 more
doaj   +1 more source

Experience of Fertility Preservation Among Younger People Diagnosed with Cancer

, 2010
Of the 293,600 cancers diagnosed annually in the UK, 11% occur in the 15- to 49-year age group. Fertility preservation options exist for those faced with the loss of fertility as a consequence of radiotherapy or chemotherapy. The aim of this study was to
Rubin, G, Stewart, J, Wilkes, S, Crosland, A, Coulson, S, Rubin, Greg, Crosland, Ann, Scott Wilkes, Stewart, Jane, Wilkes, Scott, Jane Stewart, Coulson, Susan, Greg Rubin, Susan Coulson, Ann Crosland   +14 more
core   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Asthma and Infertility: A Prospective Case–Control Study on Pregnancy and Live Birth Rates in Women With Asthma Undergoing Assisted Reproduction

The Clinical Respiratory Journal
Background Previous studies have suggested a negative impact of asthma on fertility, and it has been hypothesized that the underlying inflammation is playing an important role.
Frida E. Lundberg, Amalie H. Sneckenborg, Hanna Nilsson, Kenny A. Rodriguez‐Wallberg   +3 more
doaj   +1 more source

Fertility preservation in women

, 2021
Préservation de la fertilité: état de la ...
Dolmans, Marie-Madeleine, Fertility preservation in women   +1 more
core