Results 81 to 90 of about 140,431 (187)

Paternal ribosome biogenesis dysfunction caused by cyclophosphamide-busulfan chemotherapy contributes to early embryonic developmental impairment in mice

Journal of Translational Medicine
Background Combined cyclophosphamide (CTX) and busulfan (BUS) chemotherapy, while effective against malignancies, poses significant risks to male reproductive health. This study systematically investigates the proteomic basis underlying CTX + BUS-induced
Xin Li, Zexin Bian, Xialu Liu, Liyun Cao, Peipei Liu, Hongying Xu, Yan Zhao, Jun Tan   +7 more
doaj   +1 more source

The Moon and the Mystery: Expanding Our Horizons [PDF]

, 1989
(Excerpt) Easter arrived early this year. Only rarely does the festival come on its earliest possible date, March 22. (It last did so in 1818 and will not do so again until 2285.) But not uncommonly Easter comes toward the end of March; it was March 26 ...
Pfatteicher, Phillip H
core   +1 more source

Metformin modulates the TXNIP-NLRP3-GSDMD pathway to improve diabetic bladder dysfunction

Scientific Reports
To validate the therapeutic efficacy of metformin on diabetic bladder dysfunction (DBD) and further elucidate whether the TXNIP-NLRP3-GSDMD axis serves as a target for metformin in ameliorating DBD. C57BL/6J mice were induced with diet-induced obesity by
Bincheng Huang, Jin Zhang, Haifu Tian, Shuai Ren, Keming Chen, Jiajin Feng, Shuzhe Fan, Yunshang Tuo, Xuehao Wang, Leyi Yu, Cunling Ma, Qingjie Peng, Xiaojiang Chen, Rui He, Guangyong Li   +14 more
doaj   +1 more source

A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy

Frontiers in Pharmacology
The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for ovarian cancer by modulating the tumor microenvironment.
Yizheng Zu, Yizheng Zu, Min Li, Min Li, Ruyue Li, Ruyue Li, Shaohan Ma, Shaohan Ma, Yu’e Yang, Yu’e Yang, Shun Zhang, Yuan Ma, Yuan Ma, Tiantian Wu, Chunfang Ha, Chunfang Ha   +15 more
doaj   +1 more source

Progestin-primed ovarian stimulation for oocyte cryopreservation in patients with nonmedical indications: a case–control study

Reproductive Biology and Endocrinology
Background The PPOS (Progestin Primed Ovarian Stimulation) protocol has been evaluated and has proved its effectiveness in preventing the LH (luteinizing hormone) surge.
Ophélie Sounigo, Léah Cohen Aloro, Michael Grynberg, Céleste Becquart, Maxence Majer, Vincent Puy, Christophe Sifer, Claire Vinolas, Florence Eustache, Laetita Hesters, Anne Mayeur, Isabelle Cedrin-Durnerin, Charlotte Sonigo, Maeliss Peigné   +13 more
doaj   +1 more source

DNA breakpoints and free DNA fragments as potential predictors of infertility

Scientific Reports
The study investigated the impact of varicocele on male infertility by analyzing sperm samples from 42 varicocele patients and 22 healthy individuals.
Yue Zhou, Juan Wang, Fan Zhang, Liguo Pei, Yue Chang, Bei Yan, Hongyan Wang   +6 more
doaj   +1 more source

Psychological aspects of fertility preservation in men and women affected by cancer and other life-threatening diseases [PDF]

, 2017
BACKGROUND With advances in treatment, the number of young cancer survivors who may benefit from fertility preservation is growing. The aim of this study was to review the literature investigating psychological aspects of fertility issues and fertility ...
Bitzer, Johannes, Tschudin, Sibil
core  

Outcomes of SARS‐CoV‐2 infection in early pregnancy—A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica
Introduction Available data on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and pregnancy outcomes mostly refer to women contracting the infection during advanced pregnancy or close to delivery.
Kenny A. Rodriguez‐Wallberg, Hanna P. Nilsson, Emelie Bergman Røthe, Allan Zhao, Prakesh S. Shah, Ganesh Acharya   +5 more
doaj   +1 more source

Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model

Frontiers in Endocrinology
IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclophosphamide and other cytotoxic drugs are currently understood through two main explanatory theories: apoptosis and over-activation ...
Xia Hao, Xia Hao, Arturo Reyes Palomares, Arturo Reyes Palomares, Amandine Anastácio, Amandine Anastácio, Kui Liu, Kui Liu, Kenny A. Rodriguez-Wallberg, Kenny A. Rodriguez-Wallberg, Kenny A. Rodriguez-Wallberg   +10 more
doaj   +1 more source

Knowledge and perceptions of infertility in female cancer survivors and their parents [PDF]

, 2018
Gettinger, Katie, Hayashi, Robert J, Henry, Jennifer, Mohrmann, Caroline, Sandheinrich, Taryn, Wondmeneh, Sarah B   +5 more
core   +2 more sources