Results 61 to 70 of about 955,198 (296)

Fertility preservation options in breast cancer patients. [PDF]

, 2015
The purpose of this review is to analyse current options for fertility preservation in young women with breast cancer (BC). Considering an increasing number of BC survivors, owing to improvements in cancer treatment and delaying of childbearing ...
Franulić, Daniela, Orešković, Slavko, Juras, Josip, von Wolff, Michael, Klepac-Pulanić, Tajana, Čehić, Ermin, Kasum, Miro   +6 more
core   +2 more sources

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Fertility preservation in >1,000 patients: patient's characteristics, spectrum, efficacy and risks of applied preservation techniques [PDF]

, 2010
Data on the characteristics of female patients counselled for fertility preservation and the efficacy and risk of the applied procedures are still poor.
Lawrenz, Barbara, Barbara Lawrenz, Thomas Strowitzki, von Wolff, Michael, Kupka, Markus S, Markus S. Kupka, Michael von Wolff, Jauckus, Julia, Julia Jauckus, Strowitzki, Thomas   +9 more
core   +2 more sources

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Study on the mechanism of black Chinese wolfberry (Lycium ruthenicum Murr.) polyphenols relieving male urogenital damage caused by benzophenone-3 based on network pharmacology

Guangxi Yike Daxue xuebao
Objective To investigate the effects of the polyphenols extracted from Lycium ruthenicum Murr. (L. ruthenicum) on male urogenital damage caused by benzophenone-3 (BP-3) and its mechanism.
SUN Jiahe, DIAO Hong, YANG Haixin, CHEN Xuying, WANG Haowen, GAO Yanrong, XU Haiming, LI Hongmei   +7 more
doaj   +1 more source

Fertility Preservation in Hypogonadal Men

, 2017
Increasing numbers of men in the United States are seeking treatment for symptomatic hypogonadism with testosterone supplementation therapy (TST). In addition, the use of anabolic-androgenic steroids (AAS) is also increasing. Our current knowledge of the
Carrasquillo, Robert J, Robert J. Carrasquillo, Ramasamy, Ranjith, Ranjith Ramasamy   +3 more
core   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Integrative network toxicology and molecular docking reveal epigenetic and endocrine-disrupting mechanisms of PFAS in ovarian cancer

Frontiers in Pharmacology
ObjectivePer- and polyfluoroalkyl substances (PFAS) are omnipresent, persistent contaminants associated with rising ovarian cancer incidence; however, the molecular circuitry linking PFAS to ovarian tumorigenesis remains obscure.MethodsHere, an ...
Yulu Wang, Xueli Liu, Yanan Ding, Zhanjie Zhao, Haotian Chen, Haotian Chen, Xiaojuan Wu, Xiaojuan Wu, Yanzhou Yang, Pengge Pan, Luyi Li, Luyi Li, Hui Gao   +12 more
doaj   +1 more source