Results 61 to 70 of about 1,000,776 (293)

Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development

Clinical and Translational Medicine, 2023
Objective To reveal whether gut microbiota and their metabolites are correlated with oocyte quality decline caused by circadian rhythm disruption, and to search possible approaches for improving oocyte quality.
Ang Li, Fei Li, Wei Song, Zi‐Li Lei, Qian‐Qian Sha, Shao‐Yuan Liu, Chang‐Yin Zhou, Xue Zhang, Xiao‐Zhen Li, Heide Schatten, Teng Zhang, Qing‐Yuan Sun, Xiang‐Hong Ou   +12 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Impact of ovarian stimulation duration in GnRH antagonist protocols on the cumulative ongoing pregnancy rate in women with normal ovarian reserve: a cohort study

Reproductive Biology and Endocrinology
Background The optimal duration of ovarian stimulation in GnRH antagonist protocols remains insufficiently explored, despite its potential impact on oocyte quality, embryo development, and endometrial receptivity.
Leah Cohen Aloro, Emine Saïs, Céleste Becquart, Hélène Thomas, Fatoumata Souare, Ines Sellami, Anne Mayeur, Laetitia Hesters, Michaël Grynberg, Charlotte Sonigo   +9 more
doaj   +1 more source

Fertility Preservation in Hypogonadal Men

, 2017
Increasing numbers of men in the United States are seeking treatment for symptomatic hypogonadism with testosterone supplementation therapy (TST). In addition, the use of anabolic-androgenic steroids (AAS) is also increasing. Our current knowledge of the
Carrasquillo, Robert J, Robert J. Carrasquillo, Ramasamy, Ranjith, Ranjith Ramasamy   +3 more
core   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Integration of transcriptomics and metabolomics reveals the mechanism of Lycium barbarum polysaccharides inhibited MCF-7 cell proliferation

Scientific Reports
Breast cancer, as a highly prevalent malignant tumor among women, has a consistently high mortality rate due to metastasis and drug resistance. Lycium barbarum polysaccharides (LBP), which have been reported to have significant anti-tumor activity, have ...
Liyang Ding, Yitong Shang, Zhen Zhang, Hong Yang, Yu Deng, Tiantian He, Guoqin Yang, Jiaxue Ma, Xufeng Fu, Xing Du   +9 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Colossal Magnetic‐Field‐Induced Anomalous Hall Conductivity in a Kagome Antiferromagnet YMn6Sn6

Advanced Science, EarlyView.
Magnetic‐field‐driven spin canting in the kagome antiferromagnet YMn6Sn6${\rm YMn}_6{\rm Sn}_6$ reshapes flat and Dirac bands near the Fermi level, redistributing Berry curvature and producing colossal anomalous Hall conductivity. The study reveals how magnetic configuration and clean‐limit skew scattering cooperate to amplify Hall transport, offering ...
Minhyuk Choi, Hoil Kim, Minki Sung, Hyeongwoo Seo, Joonyoung Choi, Jaeyoung Kim, Younjung Jo, Han Woong Yeom, Kyung‐Hwan Jin, Jun Sung Kim   +9 more
wiley   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Global Burden and Temporal Trends of Early‐Onset Tracheal, Bronchial, and Lung Cancer: An Analysis of GLOBOCAN 2022 and GBD 2023 Data

Advanced Science, EarlyView.
This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian, Weihao Zhang, Yao Lu, Bruce F. O'Hara, Jingjing Hu, Hanqi Feng, Jing Di, Lei Zhang, Xueying Yang   +8 more
wiley   +1 more source