Results 131 to 140 of about 941,604 (390)

Implications of non-physiological ovarian primordial follicle activation for fertility preservation.

Endocrine reviews, 2020
In recent years, ovarian tissue cryopreservation has rapidly developed as a successful method for preserving the fertility of girls and young women with cancer or benign conditions requiring gonadotoxic therapy, and is now becoming widely recognized as ...
J. Grosbois, M. Devos, I. Demeestere
semanticscholar   +1 more source

Addressing decisional conflict about fertility preservation - helping young female cancer survivors' family planning decisions [PDF]

, 2017
Background: Health professionals are challenged by a growing number of young long term cancer survivors with their specific needs with regard to family planning.
Boivin, Jacky, Dallenbach, Rosanna Zanetti, Ehrbar, Verena, Moffat, Rebecca, Muller, Madleina, Rochlitz, Christoph, Tschudin, Sibil, Urech, Corinne   +7 more
core   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Fertility preservation before breast cancer treatment appears unlikely to affect disease‐free survival at a median follow‐up of 43 months after fertility‐preservation consultation

Cancer, 2020
The objective of this study was to determine whether fertility preservation (FP) with oocyte/embryo cryopreservation is associated with differences in disease‐free survival (DFS).
J. Letourneau, Kaitlyn Wald, N. Sinha, Flor Juarez-Hernandez, E. Harris, M. Cedars, C. McCulloch, M. Dolezal, A. J. Chien, M. Rosen   +9 more
semanticscholar   +1 more source

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

Advanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer, Keiichiro Kushiro, Bhawana Shrestha, Yong Zhu, Alysha Panjwani, Lauren Dawson, Haley Flowers, Kathleen L. Vincent, Samuel K. Lai   +8 more
wiley   +1 more source

Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency

Stem Cell Research & Therapy
Background Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesicles (ADSC-EVs) show more safety ...
Yanquan Li, Feng Chen, Wei Zhao, Di Sun, Li Zhang, Rui Qiao, Qianhui Hu, Songmao Li, Boyuan Chen, Haixia Ding, Meiling Zhang, Qing Zhang, Fanghao Guo, Wen Li   +13 more
doaj   +1 more source

The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo

Ecotoxicology and Environmental Safety
5-Fluorouracil (5-FU), a chemotherapeutic drug used to treat a variety of cancers, can enter the environment through different routes, causing serious public health and environmental concerns.
Wenzheng Yuan, Guojie Ji, Xiaowei Shi, Zhibin Sun, Chenyan Liu, Yangyang Yu, Wenmi Li, Xiaoyi Wang, Huanhuan Hu   +8 more
doaj   +1 more source

Depth‐Dependence Changes in Soil Stoichiometry in China's Croplands Over the Past Four Decades

Advanced Science, EarlyView.
This study reveals depth‐dependent changes in soil C:N:P ratios across Chinese croplands over four decades. Changes in stoichiometry vary markedly between topsoil and subsoil, with initial soil C:N:P ratios playing a key role in determining their trajectories.
Xiaodong Sun, Zhenghu Zhou, Yiqi Luo, Qingzhu Gao, Hu Li, Shuo Liu, Minggang Xu, Yu'e Li, Andong Cai   +8 more
wiley   +1 more source

Cryopreservation of equine oocytes: looking into the crystal ball [PDF]

, 2020
In vitro embryo production has evolved rapidly in the horse over the past decade, but blastocyst rates from vitrified equine oocytes remain quite poor and further research is needed to warrant application.
Angel Velez, Daniel, De Coster, Tine, Smits, Katrien, Van Soom, Ann, Woelders, Henri   +4 more
core   +2 more sources

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

Advanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu   +13 more
wiley   +1 more source