Results 41 to 50 of about 28,500 (214)

Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

Cell & Bioscience, 2021
Background Autophagy is required for oogenesis and plays a critical role in response to aging caused by oxidative stress. However, there have been no reports on regulation of cytoprotective autophagy in female germline stem cells (FGSCs) in response to ...
Xiaoyan Yuan, Geng. G. Tian, Xiuying Pei, Xiaopeng Hu, Ji Wu   +4 more
doaj   +1 more source

Fertility Preservation

Bezmialem Science, 2018
Gonad cells (oocyte or spermatozoon) and tissues (ovary, testicle) are protected from gonadotoxic exposure to ensure the continuity of fertility due to medical interventions such as chemotherapy, radiotherapy, surgery, and the other non-oncological reasons.
openaire   +2 more sources

Relative safety of various spermatogenic stem cell purification methods for application in spermatogenic stem cell transplantation

Stem Cell Research & Therapy, 2019
Background Spermatogonial stem cell (SSC) transplantation technology as a promising option for male fertility preservation has received increasing attention, along with efficient SSC purification technology as a necessary technical support; however, the ...
Jia Tian, Ke Ma, Cheng-bin Pei, Shao-hua Zhang, Xue Li, Yue Zhou, Bei Yan, Hong-yan Wang, Liang-hong Ma   +8 more
doaj   +1 more source

Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells

BMC Cancer, 2023
Background Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC).
Xingchen Dai, Xinyi Shi, Mingxiu Luo, Pu Li, Yujing Gao   +4 more
doaj   +1 more source

Study on the mechanism of black Chinese wolfberry (Lycium ruthenicum Murr.) polyphenols relieving male urogenital damage caused by benzophenone-3 based on network pharmacology

Guangxi Yike Daxue xuebao
Objective To investigate the effects of the polyphenols extracted from Lycium ruthenicum Murr. (L. ruthenicum) on male urogenital damage caused by benzophenone-3 (BP-3) and its mechanism.
SUN Jiahe, DIAO Hong, YANG Haixin, CHEN Xuying, WANG Haowen, GAO Yanrong, XU Haiming, LI Hongmei   +7 more
doaj   +1 more source

α-Linolenic acid regulates macrophages via GPR120-NLRP3 inflammasome pathway to ameliorate diabetic rats

Journal of Functional Foods, 2022
Type 2 diabetes mellitus (T2DM) is closely associated with chronic low-grade inflammation. Accumulating evidences suggest that GPR120 activation and NLRP3 inflammasome suppression contribute to ameliorate chronic inflammation.
Yuanyuan Liu, Mixue Guo, Yiwei Li, Ting Wang, Yi Ren, Rui Wang, Xin Jiang, Xiaoxia Zhang, Jianying Tian, Hao Wang   +9 more
doaj  

Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes

Reproductive Biology and Endocrinology, 2020
Oocyte activation inefficiency is one of the reasons for female infertility and Ca2+ functions play a critical role in the regulation of oocyte activation.
Feng Wang, Ang Li, Tie-Gang Meng, Le-Yun Wang, Li-Juan Wang, Yi Hou, Heide Schatten, Qing-Yuan Sun, Xiang-Hong Ou   +8 more
doaj   +1 more source

Fertility preservation in women with cancer [PDF]

The Lancet, 2014
Enhanced long-term survival rates of young women with cancer and advances in reproductive medicine and cryobiology have culminated in an increased interest in fertility preservation methods in girls and young women with cancer. Present data suggest that young patients with cancer should be referred for fertility preservation counselling quickly to help
De Vos, Michel, Smitz, Johan, Woodruff, Teresa K   +2 more
openaire   +4 more sources

Dermatoglyphs in Coronary Artery Disease Among Ningxia Population of North China [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Coronary artery disease (CAD) is an enormous health problem in the world. Dermatoglyphs are cutaneous ridges on the fingers, palms, and soles, formed by genetic regulation and control during early intrauterine life.
Hong LU, Wenli Qian, Zhi Geng, Youjing Sheng, Haochen Yu, Zhanbing Ma, Zhenghao Huo   +6 more
doaj   +1 more source

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

Nature Communications, 2020
How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos ...
Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan   +8 more
doaj   +1 more source