Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection [PDF]
Frontiers in Endocrinology, 2022 Fertilization failure during assisted reproductive technologies (ART) is often unpredictable, as this failure is encountered only after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been performed.
Yamei Xue +4 more
doaj +6 more sources
Total fertilization failure with in vitro fertilization-intracytoplasmic sperm injection related to WEE2 mutation highlights emerging importance of genetic causes of in vitro fertilization failure [PDF]
F&S Reports, 2022 Objective: To report a unique case of total fertilization failure (TFF) after in vitro fertilization with intracytoplasmic sperm injection related to homozygous WEE2 gene mutation and summarize the current literature and management of TFF.
Hillary S. Weiner, M.B.E. +5 more
doaj +4 more sources
Development and validation of a clinical prediction model of fertilization failure during routine IVF cycles [PDF]
Frontiers in Endocrinology, 2023 PurposeThis study aims to create and validate a clinical model that predict the probability of fertilization failure in routine in-vitro fertilization (IVF) cycles.MethodsThis study employed a retrospective methodology, gathering data from 1770 couples ...
Liu Xingnan, Zhang Na
doaj +2 more sources
Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure [PDF]
Frontiers in Cell and Developmental Biology, 2022 The SEPTIN12 gene has been associated with male infertility. Male Septin12+/− chimera mice were infertile, supporting the prevailing view that SEPTIN12 haploinsufficiency causes male infertility.
Haixia Chen +9 more
doaj +2 more sources
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect [PDF]
EMBO Molecular Medicine, 2022 Total fertilization failure (TFF) is an important cause of infertility; however, the genetic basis of TFF caused by male factors remains to be clarified.
Jing Dai +12 more
doaj +2 more sources
Early rescue oocyte activation at 5 h post-ICSI is a useful strategy for avoiding unexpected fertilization failure and low fertilization in ICSI cycles [PDF]
Frontiers in Endocrinology, 2023 IntroductionAttempts to artificially activate unfertilized oocytes at 24 h post intracytoplasmic sperm injection (ICSI) have generally resulted in poor outcomes.
Lintao Xue +12 more
doaj +2 more sources
Artificial oocyte activation with Ca2+ ionophore improves reproductive outcomes in patients with fertilization failure and poor embryo development in previous ICSI cycles [PDF]
Frontiers in Endocrinology, 2023 Research questionDoes artificial oocyte activation (AOA) by a calcium ionophore (ionomycin) improve the previous fertilization failure or poor embryo development of intracytoplasmic sperm injection (ICSI) account for male factor infertility or other ...
Jing Ling Ruan +7 more
doaj +2 more sources
Total fertilization failure and idiopathic subfertility [PDF]
Reproductive Biology and Endocrinology, 2009 Background To gain more insight in whether failure of intrauterine insemination (IUI) treatment in patients with idiopathic subfertility could be related to diminished fertilization, the aim of this study is to compare the fertilization of an initial IVF
Goverde Angelique J +4 more
doaj +4 more sources
The efficacy of ionomycin - induced artificial oocyte activation in preventing fertilization failure in an ICSI cycle: an eight - year retrospective study [PDF]
Journal of Ovarian ResearchBackground Artificial oocyte activation (AOA) procedure may prevent the occurrence of fertilization failure following ICSI; however, the specific efficacy of AOA remains controversial.
Ming Li +7 more
doaj +2 more sources
Relationship between sperm quality and total fertilization failure in intracytoplasmic sperm injection and in vitro fertilization cycles: A cross-sectional study [PDF]
International Journal of Reproductive BioMedicine, 2022 Background: Total fertilization failure (TFF) is associated with essential mechanistic and cellular events. Objective: The present study is a comprehensive examination of detrimental effects with well-known assays for predicting TFF in conventional in ...
Hassan Safari +5 more
doaj +2 more sources