Results 31 to 40 of about 2,639,951 (318)

In vitro production of bovine embryos [PDF]

open access: yesVeterinarski Glasnik, 2003
Biotechnology is used for the purpose of improving production, and developing animal and pharmaceutical products. In roder to achieve these objectives, it is necessary to manipulate these processes.
Pavlović Vojislav, Aleksić Jelena
doaj   +1 more source

Effect of melatonin on maturation capacity and fertilization of Nili-Ravi buffalo (Bubalus bubalis) oocytes [PDF]

open access: yesOpen Veterinary Journal, 2016
This study evaluated the effect of melatonin supplementation of in vitro maturation media on in vitro maturation (IVM) and in vitro fertilization (IVF) rate of buffalo oocytes.
G. Nagina, A. Asima, U. Nemat, A. Shamim
doaj   +1 more source

Human Blastocyst Classification after In Vitro Fertilization Using Deep Learning [PDF]

open access: yesarXiv, 2020
Embryo quality assessment after in vitro fertilization (IVF) is primarily done visually by embryologists. Variability among assessors, however, remains one of the main causes of the low success rate of IVF. This study aims to develop an automated embryo assessment based on a deep learning model.
arxiv  

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

open access: yesMolecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen   +6 more
wiley   +1 more source

The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome

open access: yesBalkan Medical Journal, 2018
Background: Oxidative stress has been proposed as a potential trigger in the etiopathogenesis of polycystic ovary syndrome-related infertility. Thiol/disulphide homeostasis, a recently identified oxidative stress marker, is one of the antioxidant ...
Esra Nur Tola   +5 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Effect of morphokinetics and morphological dynamics of cleavage stage on embryo developmental potential: A time-lapse study

open access: yesTaiwanese Journal of Obstetrics & Gynecology, 2018
Objective: Using a non-invasive method to select the most competent embryo is essential in in vitro fertilization (IVF). Since the beginning of clinical application of time-lapse technology, several studies have proposed models using the time-lapse ...
Shiao-Hsuan Yang   +6 more
doaj   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

open access: yesAdvanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua   +5 more
wiley   +1 more source

Challenges and Considerations during In Vitro Production of Porcine Embryos

open access: yesCells, 2021
Genetically modified pigs have become valuable tools for generating advances in animal agriculture and human medicine. Importantly, in vitro production and manipulation of embryos is an essential step in the process of creating porcine models.
Paula R. Chen   +4 more
doaj   +1 more source

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