Results 41 to 50 of about 58,955 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Deserción de estudiantes universitarios por embarazo

CuidArte, 2013
La deserción de estudiantes universitarios es un conflicto muy antiguo, el cual se presentaba por un bajo rendimiento y por falta de recursos económicos.
Belen Moreno Torres, Gerardo Arellano Jarillo, Mariana Colin Anastasio, Alfonso Lomas Sánchez, Laura Sánchez Ramírez   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Reductive transformation of hexabromocyclododecane (HBCD) by FeS

, 2016
Both iron monosulfide (FeS) and brominated flame retardants (BFRs) are widely found at relatively high levels in anoxic sediments, but little is known about the reactions of FeS with BFRs.
Li, Dan, Yu, Zhiqiang, Huang, Weilin, Zhong, Yin, Peng, Ping'an   +4 more
core   +1 more source

Efectividad de un manual de apoyo para el correcto llenado de la hoja de Enfermería

CuidArte, 2016
La presente investigación ha surgido por la necesidad de conocer el grado de cumplimentación del llenado de la hoja de Enfermería ya que durante la formación académica, los estudiantes han observado que no existe un criterio único para el correcto ...
Diana Jazmín Reyna Plácido, Tania Marisela Cuellar Pineda, Jesús Alberto Gómez Zúñiga, Fernando Zamora Canova, Javier Alonso Trujillo   +4 more
doaj   +1 more source

Rhabdoid tumor of the thyroid gland: a variant of anaplastic carcinoma, case report with review of the literature

PAMJ Clinical Medicine, 2020
Anaplastic thyroid carcinoma (ATC) with rhabdoid features is extremely rare and only few cases have been reported in literature. We report a case of ATC with rhabdoid features in a 66-year-old female, who presented with a rapidly enlarging neck mass ...
Amal Douida, Layla Tahiri, Mohamed Nour-Dine Elalami Elamine, Hind Elfatemi, Laila Chbani, Nawal Hammas   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Efecto del licuado de avena con manzana sobre dislipidemias y sobrepeso-obesidad.

CuidArte, 2012
Durante los últimos años se ha observado un aumento en la prevalencia de enfermedades a causa del sedentarismo y consumo de una dieta rica en grasas saturadas.
Javier Alonso Trujillo, Ricardo Bautista Vargas, Diana Janet Calzada Tovar, María de Jesús Gutiérrez Bautista, Rodrigo Alejandro Mendoza Martínez   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Comportamiento creativo: efectos de la variabilidad y secuencia del entrenamiento

Avances en Psicología Latinoamericana, 2014
Diversos estudios han reportado que, bajo condiciones variables de entrenamiento, el éxito en la transferencia de lo aprendido es mayor que bajo condiciones de entrenamiento constantes.
Claudio Carpio, Virginia Pacheco, Germán Morales, Rosalinda Arroyo Hernández, Linda Pacheco-Lechón   +4 more
doaj   +1 more source