Results 1 to 10 of about 2,290,510 (294)

On Heterogeneous Neighbor Discovery in Wireless Sensor Networks [PDF]

, 2014
Neighbor discovery plays a crucial role in the formation of wireless sensor networks and mobile networks where the power of sensors (or mobile devices) is constrained.
Bian, Kaigui, Chen, Lin, Chen, Lin, Fan, Ruolin, Gerla, Mario, Li, Xiaoming, Wang, Tao   +6 more
core   +4 more sources

Synergistic anti‐depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice

Neuropsychopharmacology Reports, 2023
Aim Selective serotonin reuptake inhibitors (SSRIs) are used to treat major depressive disorder (MDD) and other psychiatric disorders (e.g., obsessive compulsive disorder, social anxiety disorder, and panic disorder).
Naoki Amada, Tsuyoshi Hirose, Mikio Suzuki, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda, Tetsuro Kikuchi   +6 more
doaj   +1 more source

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

Communications Biology, 2022
A G protein-coupled receptors (GPCRs) phosphorylation assay for cell culture plates can be used for ligand profiling and inhibitor screening, as evidenced by the identification of two GRK inhibitor compounds.
Johanna Kaufmann, Nina Kathleen Blum, Falko Nagel, Anna Schuler, Julia Drube, Carsten Degenhart, Julian Engel, Jan Eicke Eickhoff, Pooja Dasgupta, Sebastian Fritzwanker, Maria Guastadisegni, Clemens Schulte, Elke Miess-Tanneberg, Hans Michael Maric, Mariana Spetea, Andrea Kliewer, Matthias Baumann, Bert Klebl, Rainer K. Reinscheid, Carsten Hoffmann, Stefan Schulz   +20 more
doaj   +1 more source

Rapid Quantification of Molecular Diversity for Selective Database Acquisition [PDF]

, 1997
There is an increasing need to expand the structural diversity of the molecules investigated in lead-discovery programs. One way in which this can be achieved is by acquiring external datasets that will enhance an existing database.
Ash J. E., Ashton M. J., Barnard J. M., Basak S. C., Basak S. C., Boyd S. M., David B. Turner, Downs G. M., Downs G. M., Holliday J. D., Hu C.-Y., Kearsley S. K., Martin E. J., Martin Y. C., Nilakantan R., Peter Willett, Shemetulskis N. E., Simon M. Tyrrell, Voorhees E. M, Willett P.   +19 more
core   +1 more source

Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox

SLAS Discovery, 2018
There has been much debate around the success rates of various screening strategies to identify starting points for drug discovery. Although high-throughput target-based and phenotypic screening has been the focus of this debate, techniques such as fragment screening, virtual screening, and DNA-encoded library screening are also increasingly reported ...
Melanie, Leveridge, Chun-Wa, Chung, Jeffrey W, Gross, Christopher B, Phelps, Darren, Green   +4 more
openaire   +2 more sources

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

Nature Communications, 2023
Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme’s function in the brain hold great promise for treating the neurological ...
Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia   +25 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease

Frontiers in Immunology, 2018
Overexpression of interleukin-15 (IL-15) is linked with immunopathology of several autoimmune disorders including celiac disease. Here, we utilized an anti-human IL-15 antibody 04H04 (anti-IL-15) to reverse immunopathogenesis of celiac disease.
Karol Sestak, Karol Sestak, Jason P. Dufour, David X. Liu, Namita Rout, Xavier Alvarez, James Blanchard, Anne Faldas, David J. Laine, Adam W. Clarke, Anthony G. Doyle   +10 more
doaj   +1 more source

Creating a more strategic small molecule biophysical hit characterization workflow

SLAS Discovery
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns.
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder   +11 more
doaj   +1 more source

Discovering SUSY with $m_0^2 < 0$ in the First LHC Physics Run

, 2006
In minimal supergravity, the parameter space where the slepton is the LSP is usually neglected, because of strong constraints on charged dark matter. When the gravitino is the true LSP, this region avoids these constraints and offers spectacular collider
Rajaraman, Arvind, Smith, Bryan T.
core   +1 more source