Results 31 to 40 of about 2,290,510 (294)
Acta Pharmaceutica, 2015 PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated.
Suzuki Osamu +4 more
doaj +1 more source
, 2015 We describe new computer-based search strategies for extreme functions for the Gomory--Johnson infinite group problem. They lead to the discovery of new extreme functions, whose existence settles several open questions.Comment: 54 pages, many ...
Köppe, Matthias, Zhou, Yuan
core +1 more source
Frontiers in Chemistry, 2019 High throughput screening (HTS) is an important component of lead discovery, with virtual screening playing an increasingly important role. Both methods typically suffer from lack of sensitivity and specificity against their true biological targets. With
Ruifeng Liu +4 more
doaj +1 more source
A Bidirectional Permeability Assay for beyond Rule of 5 Compounds
Pharmaceutics, 2021 Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved ...
Yunhai Cui +6 more
doaj +1 more source
EMBO Molecular Medicine, 2014 Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF‐BP1, MULE) associates with both MYC and the MYC‐associated protein MIZ1.
Stefanie Peter +16 more
doaj +1 more source
Future Science OA, 2023 Tweetable abstract It is proposed that gut microbiome of species like cockroaches may offer a potential source of novel mechanisms/molecules that can be translated into humans to safeguard astronauts against stressors of the space environment during deep
Ruqaiyyah Siddiqui +2 more
doaj +1 more source
Talk More Listen Less: Energy-Efficient Neighbor Discovery in Wireless Sensor Networks
, 2016 Neighbor discovery is a fundamental service for initialization and managing network dynamics in wireless sensor networks and mobile sensing applications. In this paper, we present a novel design principle named Talk More Listen Less (TMLL) to reduce idle-
Li, Shining +3 more
core +1 more source
QCD critical point and event-by-event fluctuations in heavy ion collisions [PDF]
, 1999 A summary of work done in collaboration with K. Rajagopal and E. Shuryak. We show how heavy ion collision experiments, in particular, event-by-event fluctuation measurements, can lead to the discovery of the critical point on the phase diagram of QCD ...
Berges +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source
Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors
Molecules6-Aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines have promising properties as colony-stimulating factor 1 receptor (CSF1R) inhibitors. Inspired by these antagonists, two series of 1,2,3-triazole analogues (28 compounds) were synthesized and evaluated as CSF1R ...
Srinivasulu Cherukupalli +6 more
doaj +1 more source