Results 41 to 50 of about 754,901 (303)

Price discovery in spot and futures markets: a reconsideration [PDF]

, 2009
We reconsider the issue of price discovery in spot and futures markets. We use a threshold error correction model to allow for arbitrage operations to have an impact on the return dynamics.
Theissen, Erik
core  

A Perspective on Synthetic Biology in Drug Discovery and Development - Current Impact and Future Opportunities [PDF]

, 2021
The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline’s
Gossing, Michael,, Hayes, Martin A., Gossing, Michael, Scott, Louis H., Scott, Louis H.,, Romero, Elvira,, David, Florian,, David, Florian, Romero, Elvira, Wigglesworth, Mark J.,, Davis, Andrew M.,, Hayes, Martin A.,, Davis, Andrew M., Wigglesworth, Mark J.   +13 more
core   +1 more source

Orthosteric STING inhibition elucidates molecular correction of SAVI STING

Nature Communications
While the progression of STING activators into the clinic has been successful, the discovery and clinical progression of STING inhibitors remain elusive. Questions persist about the molecular properties needed to distinguish between a STING activator and
Tao Xie, Max Ruzanov, David Critton, Leidy Merselis, Joseph Naglich, John S. Sack, Ping Zhang, Chunshan Xie, Jeffrey Tredup, Laurel B. Stine, Cameron Messier, David L. Hope, Janet Caceres-Cortes, Luciano Mueller, Alaric J. Dyckman, John A. Newitt, Asmita Choudhury, Stephen C. Wilson   +17 more
doaj   +1 more source

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Pharmaceuticals
Background/Objectives: Colony stimulating factor 1 receptor kinase (CSF1R) is a well-validated molecular target in drug discovery for various reasons.
Srinivasulu Cherukupalli, Carsten Degenhart, Peter Habenberger, Anke Unger, Jan Eickhoff, Bård Helge Hoff, Eirik Sundby   +6 more
doaj   +1 more source

Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site

Frontiers in Chemistry, 2020
During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system.
Ola El Atab, Rabih Darwiche, Rabih Darwiche, Nathanyal J. Truax, Roger Schneiter, Kenneth G. Hull, Daniel Romo, Oluwatoyin A. Asojo, Oluwatoyin A. Asojo   +8 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Coaching by Guided Discovery

, 2021
Coaching by Guided Discovery Style F is characterised by the logical and sequential design of questions that lead the players to a coach’s pre-determined response. In effect, Coaching by Guided Discovery is intended to develop ‘understanding’ rather than
Pill, Shane, Brendan SueSee, Joss Rankin, Rankin, Joss, Shane Pill, SueSee, Brendan, Mitch Hewitt, Hewitt, Mitch   +7 more
core   +1 more source

Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ

SLAS Discovery
The Hippo pathway plays an important role in organ size control and tissue homeostasis. Dysregulation is involved in many pathologies, including cancer, which has attracted interest in targeting the Hippo pathway.
Blaž Andlovic, Alexander Wolf, Malgorzata Hiltmann, Bert M. Klebl, Jan Eickhoff, Christian Ottmann   +5 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Identification of pyrazolopyridazinones as PDEδ inhibitors

Nature Communications, 2016
PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low ...
Björn Papke, Sandip Murarka, Holger A Vogel, Pablo Martín-Gago, Marija Kovacevic, Dina C Truxius, Eyad K Fansa, Shehab Ismail, Gunther Zimmermann, Kaatje Heinelt, Carsten Schultz-Fademrecht, Alaa Al Saabi, Matthias Baumann, Peter Nussbaumer, Alfred Wittinghofer, Herbert Waldmann, Philippe I.H. Bastiaens   +16 more
doaj   +1 more source