Results 41 to 50 of about 2,290,510 (294)

Fermion Number Fractionization

, 2007
Solitons emerge as non-perturbative solutions of non-linear wave equations in classical and quantum theories. These are non-dispersive and localised packets of energy-remarkable properties for solutions of non-linear differential equations.
Panigrahi, Prasanta K., Rao, Kumar, Sahu, Narendra   +2 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Orthosteric STING inhibition elucidates molecular correction of SAVI STING

Nature Communications
While the progression of STING activators into the clinic has been successful, the discovery and clinical progression of STING inhibitors remain elusive. Questions persist about the molecular properties needed to distinguish between a STING activator and
Tao Xie, Max Ruzanov, David Critton, Leidy Merselis, Joseph Naglich, John S. Sack, Ping Zhang, Chunshan Xie, Jeffrey Tredup, Laurel B. Stine, Cameron Messier, David L. Hope, Janet Caceres-Cortes, Luciano Mueller, Alaric J. Dyckman, John A. Newitt, Asmita Choudhury, Stephen C. Wilson   +17 more
doaj   +1 more source

Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach

Pharmaceuticals
Background/Objectives: Colony stimulating factor 1 receptor kinase (CSF1R) is a well-validated molecular target in drug discovery for various reasons.
Srinivasulu Cherukupalli, Carsten Degenhart, Peter Habenberger, Anke Unger, Jan Eickhoff, Bård Helge Hoff, Eirik Sundby   +6 more
doaj   +1 more source

Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site

Frontiers in Chemistry, 2020
During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system.
Ola El Atab, Rabih Darwiche, Rabih Darwiche, Nathanyal J. Truax, Roger Schneiter, Kenneth G. Hull, Daniel Romo, Oluwatoyin A. Asojo, Oluwatoyin A. Asojo   +8 more
doaj   +1 more source

The Impact of Web-Scale Discovery on the Use of Electronic Resources [PDF]

, 2019
In 2015, the University of California, Berkeley, launched EBSCO Discovery Service (EDS), a web-scale discovery tool, with a goal of improving visibility and usage of collections.
Hennesy, Cody, Knabe, Ian, Ngo, Lisa
core  

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ

SLAS Discovery
The Hippo pathway plays an important role in organ size control and tissue homeostasis. Dysregulation is involved in many pathologies, including cancer, which has attracted interest in targeting the Hippo pathway.
Blaž Andlovic, Alexander Wolf, Malgorzata Hiltmann, Bert M. Klebl, Jan Eickhoff, Christian Ottmann   +5 more
doaj   +1 more source

Price discovery in spot and futures markets: a reconsideration [PDF]

, 2009
We reconsider the issue of price discovery in spot and futures markets. We use a threshold error correction model to allow for arbitrage operations to have an impact on the return dynamics.
Theissen, Erik
core  

Signals for gauge-mediated supersymmetry breaking models at the CERN LEP2 collider

, 1997
We consider a general class of models with gauge-mediated supersymmetry breaking in which the gravitino is the lightest supersymmetric particle. Several qualitatively different scenarios arise for the phenomenology of such models, depending on which ...
Ambrosanio, S., Kribs, Graham D., Martin, Stephen P.   +2 more
core   +1 more source