Results 21 to 30 of about 754,901 (303)

Lead SNPs from discovery GWAS.

, 2022
Lead SNPs from discovery GWAS.
Jianhua Zhang (6347), Poorni Adikaram (12770281), Ayo P. Doumatey (8487927), Guanjie Chen (28943), Adebowale Adeyemo (28944), Jie Zhou (28945), Charles N. Rotimi (8478951), Daniel Shriner (137188), Amy R. Bentley (7634120)   +8 more
core   +1 more source

Synergistic anti‐depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice

Neuropsychopharmacology Reports, 2023
Aim Selective serotonin reuptake inhibitors (SSRIs) are used to treat major depressive disorder (MDD) and other psychiatric disorders (e.g., obsessive compulsive disorder, social anxiety disorder, and panic disorder).
Naoki Amada, Tsuyoshi Hirose, Mikio Suzuki, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda, Tetsuro Kikuchi   +6 more
doaj   +1 more source

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

Communications Biology, 2022
A G protein-coupled receptors (GPCRs) phosphorylation assay for cell culture plates can be used for ligand profiling and inhibitor screening, as evidenced by the identification of two GRK inhibitor compounds.
Johanna Kaufmann, Nina Kathleen Blum, Falko Nagel, Anna Schuler, Julia Drube, Carsten Degenhart, Julian Engel, Jan Eicke Eickhoff, Pooja Dasgupta, Sebastian Fritzwanker, Maria Guastadisegni, Clemens Schulte, Elke Miess-Tanneberg, Hans Michael Maric, Mariana Spetea, Andrea Kliewer, Matthias Baumann, Bert Klebl, Rainer K. Reinscheid, Carsten Hoffmann, Stefan Schulz   +20 more
doaj   +1 more source

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

Nature Communications, 2023
Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme’s function in the brain hold great promise for treating the neurological ...
Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia   +25 more
doaj   +1 more source

E-selectin antagonists: fragment-based drug discovery and lead optimization by NMR and BIAcore [PDF]

, 2012
The inflammatory response consists of a well-defined and regulated multi-step cascade leading to extravasation of leukocytes from the blood to sites of inflammation. The transmigration of leukocytes is initiated by their interaction with the endothelium,
Weckerle, Céline
core   +1 more source

Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease

Frontiers in Immunology, 2018
Overexpression of interleukin-15 (IL-15) is linked with immunopathology of several autoimmune disorders including celiac disease. Here, we utilized an anti-human IL-15 antibody 04H04 (anti-IL-15) to reverse immunopathogenesis of celiac disease.
Karol Sestak, Karol Sestak, Jason P. Dufour, David X. Liu, Namita Rout, Xavier Alvarez, James Blanchard, Anne Faldas, David J. Laine, Adam W. Clarke, Anthony G. Doyle   +10 more
doaj   +1 more source

Creating a more strategic small molecule biophysical hit characterization workflow

SLAS Discovery
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns.
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder   +11 more
doaj   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa, Drewry, David H., Kessler, Albane, Pilar Manzano, M., Cotillo, Ignacio, Roquero, Irene, Alonso-Padilla, Julio, Bardera, Ana I., Navarro, Miguel, Manzano, Pilar, Brown, James R., Sherstnev, Alexander, Alvarez, Emilio, Rodríguez López, Ana, Fiandor, Jose M., Julio Martin, J., Dios-Antón, Francisco de, Kumar, Vinod, Peña, Imanol, Martin, José Julio, Gray, David W., Gray, David W.; id_orcid, Rodriguez, Ana, Navarro, M., Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo   +26 more
core   +1 more source

The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor

Acta Pharmaceutica, 2015
PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated.
Suzuki Osamu, Goto Taiji, Yoshino Toshiharu, Nakamura Satoshi, Maeda Hiroaki   +4 more
doaj   +1 more source

Lead/Drug Discovery from Natural Resources

Molecules, 2022
Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with ...
Zhihong Xu, Barrett Eichler, Eytan A. Klausner, Jetty Duffy-Matzner, Weifan Zheng   +4 more
doaj   +1 more source