Results 21 to 30 of about 2,290,510 (294)

Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy

Neuropsychopharmacology Reports, 2022
Background Deficiency of folate, an essential vitamin for DNA synthesis and methylation, is reported as a risk factor for mental disorders. Considering a possibility that folate metabolism deficit during pregnancy may disturb CNS development and increase
Naoki Amada, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda   +3 more
doaj   +1 more source

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate

Antibiotics, 2023
Bacteria of the genus Streptomyces produce various specialized metabolites. Single biosynthetic gene clusters (BGCs) can give rise to different products that can vary in terms of their biological activities.
Leonie Sagurna, Sascha Heinrich, Lara-Sophie Kaufmann, Christian Rückert-Reed, Tobias Busche, Alexander Wolf, Jan Eickhoff, Bert Klebl, Jörn Kalinowski, Julia E. Bandow   +9 more
doaj   +1 more source

Phenotypic screens, chemical genomics, and antimalarial lead discovery. [PDF]

PLoS Pathogens, 2011
Jose F Garcia-Bustos, Francisco-Javier Gamo   +1 more
doaj   +2 more sources

Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone

Molecules, 2023
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides.
Kaihua Wang, Beibei Wang, Henan Ma, Ziwen Wang, Yuxiu Liu, Qingmin Wang   +5 more
doaj   +1 more source

Biological Activity of Hybrid Molecules Based on Major Constituents of Cinnammomun verum and Thymus vulgaris Essential Oils

Life, 2023
Plants have been used by humans since ancient times due their antimicrobial and medicinal properties. Essential oils (EOs) are complex mixtures of secondary plant metabolites, including terpenoids, phenylpropanoids, and other aromatic compounds ...
Juan Valverde Sancho, Cristina Carreño Amate, María del Mar Caparrós Pérez, Omar Santana Méridas, Luis F. Julio   +4 more
doaj   +1 more source

Scalable discovery of hybrid process models in a cloud computing environment [PDF]

, 2019
Process descriptions are used to create products and deliver services. To lead better processes and services, the first step is to learn a process model.
Cheng, Long, van der Aalst, Wil, van Dongen, Boudewijn   +2 more
core   +1 more source

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

Communications Biology, 2021
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches.
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher   +12 more
doaj   +1 more source

In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery

Frontiers in Chemistry, 2020
Fragment-based drug (or lead) discovery (FBDD or FBLD) has developed in the last two decades to become a successful key technology in the pharmaceutical industry for early stage drug discovery and development.
Lauro Ribeiro de Souza Neto, José Teófilo Moreira-Filho, Bruno Junior Neves, Bruno Junior Neves, Rocío Lucía Beatriz Riveros Maidana, Rocío Lucía Beatriz Riveros Maidana, Ana Carolina Ramos Guimarães, Nicholas Furnham, Carolina Horta Andrade, Floriano Paes Silva   +9 more
doaj   +1 more source

Utility of mass spectrometry for the diagnosis of the unstable coronary plaque. [PDF]

, 2015
Mass spectrometry is a powerful technique that is used to identify unknown compounds, to quantify known materials, and to elucidate the structure and chemical properties of molecules.
Hassan, M, Jacob, SS, Yacoub, MH
core   +1 more source

Antibacterial activity of Diterpenes against Methicillin-resistant

Natural Product Communications, 2014
One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens . Of these, demethylcryptojaponol ( 2 ), 6-hydroxysalvinolone ( 3 ), hydroxyferruginol ( 4 ), and hinokiol ( 5 ) demonstrated potent ...
Courtney M. Starks, Vanessa L. Norman, Russell B. Williams, Matt G. Goering, Stephanie M. Rice, Mark O'Neil-Johnson, Gary R. Eldridge   +6 more
doaj   +1 more source