Results 11 to 20 of about 2,290,510 (294)
Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery [PDF]
Antibiotics, 2023 Fragment-based lead discovery (FBLD) is a powerful application for developing ligands as modulators of disease targets. This approach strategy involves identification of interactions between low-molecular weight compounds (100–300 Da) and their putative ...
Monika I. Konaklieva, Balbina J. Plotkin
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Lead/Drug Discovery from Natural Resources
Molecules, 2022 Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with ...
Zhihong Xu +4 more
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Multiparameter ranking of carbazoles for anti-trypanosome lead discovery [PDF]
Frontiers in Drug DiscoveryThe criteria for the progression of hits in the discovery of leads for human African trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote Trypanosoma brucei, are not standardized. Hits are advanced upon meeting thresholds for drug-
Amrita Sharma +5 more
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Process of Fragment-Based Lead Discovery—A Perspective from NMR [PDF]
Molecules, 2016 Fragment-based lead discovery (FBLD) has proven fruitful during the past two decades for a variety of targets, even challenging protein–protein interaction (PPI) systems.
Rongsheng Ma +3 more
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Efficient drug lead discovery and optimization. [PDF]
Acc Chem Res, 2009 During the 1980s, advances in the abilities to perform computer simulations of chemical and biomolecular systems and to calculate free energy changes led to the expectation that such methodology would soon show great utility for guiding molecular design.
Jorgensen WL.
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Lead Discovery Using Virtual Screening [PDF]
Lead-Seeking Approaches, 2009 The practice of virtual screening (VS) to identify chemical leads to known or novel targets is becoming a core function of the computational chemist within industry. By employing a range of techniques, when attempting to identify compounds with activity against a biological target, a small focused subset of a larger collection of compounds can be ...
Bikker J, Narasimhan L.
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BRET measurement on CCD camera-based microtiter plate readers
SLAS Discovery, 2022 NanoBRET assays, which utilize bioluminescence energy resonance transfer (BRET), have been widely adopted in drug discovery for measuring both protein-protein interactions and drug target engagement. While the EnVision and other traditional well-scanning
Kelvin F. Cho +2 more
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Communications Biology, 2021 Malvezzi et al. discuss the impact of BRD4 phosphorylation on the formation of dimers and identify the key residues necessary for this dimerization. They also discuss the differential role of monovalent and bivalents bromodomain inhibitors regarding the ...
Francesca Malvezzi +9 more
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mAbs, 2020 The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide ...
Feng Wang +17 more
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Ranking, selecting, and prioritising genes with desirability functions [PDF]
PeerJ, 2015 In functional genomics experiments, researchers often select genes to follow-up or validate from a long list of differentially expressed genes. Typically, sharp thresholds are used to bin genes into groups such as significant/non-significant or fold ...
Stanley E. Lazic
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