Results 11 to 20 of about 754,901 (303)

Ranking, selecting, and prioritising genes with desirability functions [PDF]

PeerJ, 2015
In functional genomics experiments, researchers often select genes to follow-up or validate from a long list of differentially expressed genes. Typically, sharp thresholds are used to bin genes into groups such as significant/non-significant or fold ...
Stanley E. Lazic
doaj   +2 more sources

Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy

Neuropsychopharmacology Reports, 2022
Background Deficiency of folate, an essential vitamin for DNA synthesis and methylation, is reported as a risk factor for mental disorders. Considering a possibility that folate metabolism deficit during pregnancy may disturb CNS development and increase
Naoki Amada, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda   +3 more
doaj   +1 more source

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate

Antibiotics, 2023
Bacteria of the genus Streptomyces produce various specialized metabolites. Single biosynthetic gene clusters (BGCs) can give rise to different products that can vary in terms of their biological activities.
Leonie Sagurna, Sascha Heinrich, Lara-Sophie Kaufmann, Christian Rückert-Reed, Tobias Busche, Alexander Wolf, Jan Eickhoff, Bert Klebl, Jörn Kalinowski, Julia E. Bandow   +9 more
doaj   +1 more source

Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone

Molecules, 2023
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides.
Kaihua Wang, Beibei Wang, Henan Ma, Ziwen Wang, Yuxiu Liu, Qingmin Wang   +5 more
doaj   +1 more source

Phenotypic screens, chemical genomics, and antimalarial lead discovery. [PDF]

PLoS Pathogens, 2011
Jose F Garcia-Bustos, Francisco-Javier Gamo   +1 more
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Biological Activity of Hybrid Molecules Based on Major Constituents of Cinnammomun verum and Thymus vulgaris Essential Oils

Life, 2023
Plants have been used by humans since ancient times due their antimicrobial and medicinal properties. Essential oils (EOs) are complex mixtures of secondary plant metabolites, including terpenoids, phenylpropanoids, and other aromatic compounds ...
Juan Valverde Sancho, Cristina Carreño Amate, María del Mar Caparrós Pérez, Omar Santana Méridas, Luis F. Julio   +4 more
doaj   +1 more source

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

Communications Biology, 2021
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches.
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher   +12 more
doaj   +1 more source

Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery [PDF]

, 2017
GPCR modeling approaches are widely used in the hit-to-lead (H2L) and lead optimization (LO) stages of drug discovery. The aims of these modeling approaches are to predict the 3D structures of the receptor-ligand complexes, to explore the key ...
Bodkin, MJ, Andrea Townsend-Nicholson, Michelle Southey, Inaki Morao, Townsend-Nicholson, A, Morao, I, Mike J. Bodkin, Alexander Heifetz, Heifetz, A, Southey, M   +9 more
core   +1 more source

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors [PDF]

, 2011
N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei.
Read, Kevin D., Bayliss, Tracy, Wyatt, Paul G., Norcross, Neil R., Victoria C. Smith, Laura A. T. Cleghorn, Alan H. Fairlamb, Harrison, Justin R., Kevin D. Read, Frearson, Julie A., Daniel Spinks, Suzanne Norval, Ian H. Gilbert, Stuart P. McElroy, McElroy, Stuart P., Gilbert, Ian H., Tracy Bayliss, Torrie, Leah S., Brenk, Ruth, Stojanovski, Laste, Neil R. Norcross, Leah S. Torrie, Fairlamb, Alan H.; id_orcid, Spinks, Daniel, Robinson, David A., Smith, Victoria C., Brand, Stephen, Norval, Suzanne, Ruth Brenk, Irene Hallyburton, Ferguson, Michael A. J.; id_orcid, Hallyburton, Irene, Michael A. J. Ferguson, David A. Robinson, Laste Stojanovski, Stephen Brand, Justin R. Harrison, Julie A. Frearson, Paul G. Wyatt, Cleghorn, Laura A. T.; id_orcid   +39 more
core   +1 more source

Antibacterial activity of Diterpenes against Methicillin-resistant

Natural Product Communications, 2014
One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens . Of these, demethylcryptojaponol ( 2 ), 6-hydroxysalvinolone ( 3 ), hydroxyferruginol ( 4 ), and hinokiol ( 5 ) demonstrated potent ...
Courtney M. Starks, Vanessa L. Norman, Russell B. Williams, Matt G. Goering, Stephanie M. Rice, Mark O'Neil-Johnson, Gary R. Eldridge   +6 more
doaj   +1 more source