Results 1 to 10 of about 8,896 (137)
Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin-Based Quinazoline Derivatives as Potential Antidiabetic Agents. [PDF]
Chem BiodiversA series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Jaidka S +4 more
europepmc +2 more sources
Molecular docking, synthesis, and cytotoxic evaluation of novel quinazoline-quinazolinone hybrid compounds [PDF]
Research in Pharmaceutical SciencesBackground and purpose: Cancer represents a significant public health challenge and a leading cause of mortality globally. Quinazolinones represent a class of privileged structures that exhibit a broad spectrum of biological activities such as anticancer,
Majid Azarmi +3 more
doaj +2 more sources
Setting of an import tolerance for fenazaquin in teas. [PDF]
EFSA JAbstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Gowan Crop Protection Limited submitted a request to the competent national authority in Germany to set an import tolerance for the active substance fenazaquin in teas imported from India.
European Food Safety Authority (EFSA) +10 more
europepmc +2 more sources
COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR
Jurnal Farmasi Sains dan Praktis, 2021 The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted ...
Anita Puspa Widiyana
doaj +1 more source
VEGFER-2 INHIBITORS AND QUINAZOLINE-BASED ANTICANCER AGENTS [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Inhibitors of vascular endothelial growth factor receptor -2 (VEGFR-2) are crucial biological targets for the development of novel anticancer medications.
Helmy Sakr +3 more
doaj +1 more source
Антибиотики и Химиотерапия, 2023 The study is devoted to the study of acute toxicity of a new quinazoline compound — 3-[2-Oxo-2-(4-phenylpiperazine-1-yl)ethyl]quinazoline-4(3H)-one (VMA-10-21), promising as an antimicrobial agent active against opportunistic microorganisms.
N. M. Gabitova +3 more
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Synthesis Of Some Substituted 1,2,5-Oxadiazino [2-3,b] Quinazoline And Some 1,3-Oxazole Derivatives [PDF]
مجلة التربية والعلم, 2013 In this paper the synthesis of some 1,2,5- oxadiazino [2-3,b] quinazoline and some substituted 1,3- oxazole are reported, alanine and valine were reacted with benzoyle chloride in sodium hydroxide solution to give N- benzoyle alanine or valine (1,2 ...
Yassir S. Mohamad
doaj +1 more source
Frontiers in Environmental Chemistry, 2021 Occurrence of emerging organic micropollutants in water bodies and their effects are a concern related to quality of reused water. Advanced oxidation processes have demonstrated promising results to address this challenge.
Z. Amadou Yacouba +5 more
doaj +1 more source
Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2018 Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation.
Anita Puspa Widiyana +4 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors.
Abdelfattah Hassan +6 more
doaj +1 more source