Results 11 to 20 of about 24,434,811 (177)
, 2023 Matrix metalloproteinase-13 (MMP-13) plays a critical role in the progression of unstable atherosclerosis. A series of highly potent and selective MMP-13 inhibitors were synthesized around a quinazoline-2-carboxamide scaffold to facilitate radiolabeling ...
Faduma Abdirahman +17 more
core +2 more sources
Quinazoline pharmacophore in therapeutic medicine [PDF]
, 2016 This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic ...
Ajani, Olayinka O.
core +4 more sources
Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors [PDF]
, 2022 Hematopoietic progenitor kinase 1 (HPK1) is a serine/threonine kinase that serves as the negative regulator of multiple immune signaling pathways. Genetic studies using HPK1 knockout and kinase-dead mice suggested that inhibiting HPK1 either alone or in ...
Yuting, Chen +10 more
core +1 more source
Computational investigation on natural quinazoline alkaloids as potential inhibitors of the main protease (Mpro) of SARS_CoV_2 [PDF]
, 2021 Drug discovery is still behind in the race compared to vaccine discovery in fighting COVID-19. Recently, a few alkaloids from a traditional Indian medicinal plant, Vasaka (Justicia adhatoda), have been linked computationally to the main protease (Mpro ...
Deb Ranjan, Banerjee +4 more
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Structure-Activity Relationship and Docking Study of Non-Quinazoline EGFR/VEGFR Dual Inhibitors. A Review [PDF]
Iranian Journal of Chemistry & Chemical EngineeringThe dual inhibitors of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) have been developed as a promising strategy for cancer therapy.
Fatemeh Yousefbeyk, Saeed Ghasemi
doaj +1 more source
Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114
, 2019 Seven new quinazoline-containing indole alkaloids (1–7) named aspertoryadins A–G, along with nine known ones (8–16), were isolated from the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis.
Jiu-Hui Li (4404250) +12 more
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Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
Molecules, 2009 Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical ...
Martha Cecilia Meza +4 more
doaj +1 more source
Molecules, 2001 Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoylaminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding
Miloš Sedlák +3 more
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E-Journal of Chemistry, 2009 Novel ligands containing quinazoline-4-one-8-hydroxyquinoline (QQ) merged moieties were prepared and characterized. For this anthranilic acid and 5-bromoanthranilic acid were converted respectively into 2-chloromethyl–3-(4-methyl phenyl)-3(H)-quinazoline-
R. T. Vashi, S. B. Patel
doaj +1 more source
2-Azidobenzaldehyde-Enabled Construction of Quinazoline Derivatives: A Review. [PDF]
Int J Mol SciQuinazoline is a privileged heterocyclic scaffold commonly found in numerous pharmaceuticals and bioactive natural products, known for its diverse biological activities.
Qiu W, Zhan D, Ma X, Zhang X.
europepmc +2 more sources