Results 41 to 50 of about 24,434,811 (177)

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives as potent and selective inhibitors targeting hepatitis B virus

Bangladesh Journal of Pharmacology, 2015
The construction of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives (4a–4m), by  the condensation isatoic anhydride, appropriate amines and 2-formylbenzoic acid by using silica sulfuric acid as catalyst was reported.
Jun-Fei Zhang, Bo Liu, Cong-Xin Chen
doaj   +1 more source

Tuning Ionic Liquid-Based Catalysts for CO₂ Conversion into Quinazoline-2,4(1H,3H)-diones

Molecules, 2023
Carbon capture and storage (CCS) and carbon capture and utilization (CCU) are two kinds of strategies to reduce the CO2 concentration in the atmosphere, which is emitted from the burning of fossil fuels and leads to the greenhouse effect. With the unique
Ruina Zhang, Daqing Hu, Ying Zhou, Chunliang Ge, Huayan Liu, Wenyang Fan, Lai Li, Biao Chen, Yepin Cheng, Yaoji Chen, Wei Zhang, Guokai Cui, Hanfeng Lu   +12 more
doaj   +1 more source

Expedient Synthesis of 4-Aryl Quinazoline Analogues via Direct Nucleophilic Arylation of 2-Chloroquinazoline

, 2016
A practical approach was developed for the synthesis of 4-aryl quinazoline compounds via a one-pot nucleophilic arylation of 2-chloro-quinazoline with aryl lithiums generated in situ, followed by ring oxidation.
Yang Yang, Yang, Yang
core   +1 more source

Directed Search of Biologically Active Compounds Among Hydrogenated Isoindolylalkyl(alkylaryl-,aryl-)carboxylic acids with Quinazoline Fragment that Modify the Carbohydrate Metabolism: Design, Synthesis and Modification

Acta Chimica Slovenica, 2019
An effective synthesis of (3H-quinazoline-4-ylidene)hydrazides of N-carboxyalkyl-(arylalkyl-,aryl-)isoindoline-1,3-diones, using activated N-protected aminoacids and 4-hydrazinoquinazoline was proposed in the framework methodology of directed search of ...
Yulya Victorivna Martynenko, Oleksii Mykolayovich Antypenko, Olexandr Anatolievich Brazhko, Irina Borisivna Labenska, Sergii Ivanovich Kovalenko   +4 more
doaj   +1 more source

rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one

Acta Crystallographica Section E, 2011
The chiral title compound, C21H20N4O2, crystallizes as a racemic mixture. In the crystal, molecules form centrosymmetric π-overlapping dimers [interplanar distance = 3.338 (6) Å], which are further connected along ...
Peter Grundt, Bogdana Krivogorsky, Paul D. Steffen, Matthew E. Rodstein   +3 more
doaj   +1 more source

Low‐Temperature in Situ Upgrading of Ultra‐Deep Heavy Oil Using Ni–Ce/MOF–OTf Superacid Catalysts to Enhance Energy Utilization and Sustainability

EcoEnergy, EarlyView.
A triflate‐functionalized Ni–Ce/MOF–OTf superacid enables low‐temperature (∼140°C) in situ upgrading of ultra‐deep heavy oil. It reduces viscosity by 92.11% in 12 h, maintains activity over cycles, and delivers 90.25% recovery with a lower carbon footprint by selective bond cleavage. ABSTRACT Ultra‐deep heavy oil is an important unconventional resource,
Li Wang, Ji‐Xiang Guo, Qiming Huang, Kunpeng Li, Chi Li, Yajie Wu   +5 more
wiley   +1 more source

Acid catalyzed synthesis of 2-(2-aminophenyl)quinazoline-4-amine and reaction with aromatic aldehydes

, 2016
2-(2-Aminophenyl)quinazoline-4-amine, prepared from a quinazolino[3,4-a]quinazoline, were reacted with aromatic aldehydes under conventional heating or microwave irradiation, leading to high yields of tetracyclic dihydroquinazolines.We gratefully ...
Proença, M. Fernanda R. P., Marinho, Elina Margarida Ribeiro   +1 more
core   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, EarlyView.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source