Results 61 to 70 of about 24,434,811 (177)
Fruquintinib: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Fruquintinib is a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3) that was approved, including in China, the United States, and the European Union, for the treatment of previously treated metastatic colorectal cancer (mCRC).
Xiaofei Zhou +7 more
wiley +1 more source
Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity
E-Journal of Chemistry, 2005 Pyrimidine-2-one derivatives, 2-[2-{1ʹ-(p-nitrophenyl)-6ʹ-(substituted-phenyl)-pyrimidine-2ʹ-one-4ʹ-yl}-hydrazinomethyl]-3-(p-methoxy phenyl)-quina-zoline-4(3H)-one [4a-j] have been synthesised by the condensation of p-nitro phenylurea and various ...
Ketan Mistry, K. R. Desai
doaj +1 more source
3-Benzyl-6-methyl-2-sulfanylidene-2,3-dihydroquinazolin-4(1H)-one
Acta Crystallographica Section E, 2012 In the title compound, C16H14N2OS, the quinazoline ring system is essentially planar, with a maximum deviation of 0.029 (3) Å. The dihedral angle between the quinazoline and benzene rings is 88.4 (2)°.
Hoong-Kun Fun +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 18, 28 September 2026.The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana +8 more
wiley +1 more source
2-vinyl quinazoline 3-oxides; preparation from acid induced cyclocondensation of 2-acylaminoaryloximes [PDF]
, 2007 2-Vinyl quinazoline 3-oxides 6a, 6b and 15a are useful modular building blocks for the construction of a range of heterocycles with potential biological activity, from o-[amidoalkenyl]aryloximes 5a, 5b and 14a, respectively, by cyclocondensation ...
Lawless, Elaine +3 more
core +1 more source
Archiv der Pharmazie, Volume 359, Issue 9, September 2026.We screened acrylamide bioisosteres against KRasG12C and prioritized primary hits by their GSH reactivity, labeling efficiency and specificity. The most promising fragment was combined with a KRas‐binding scaffold. Covalent binding, inhibitory activity and selectivity were confirmed via MS, NMR, biochemical and cell viability assays.
Nikolett Péczka +11 more
wiley +1 more source
Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala
, 2018 Peganum harmala L. is a medicinal plant from the Mediterranean region and Asia currently used for recreative psychoactive purposes (Ayahuasca analogue), and increasingly involved in toxic cases.
Salgado, Antonio +3 more
core +1 more source
The Design and Synthesis of a New Class of RTK/HDAC Dual-Targeted Inhibitors
Molecules, 2013 Over the years, the development of targeted medicines has made significant achievements. As a typical example, receptor tyrosine kinases (RTK) inhibitors have become important chemotherapy drugs for a variety of cancers.
Wei Lu +4 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor.
Daseul Im +5 more
doaj +1 more source
4-[(7-Fluoroquinazolin-4-yl)oxy]aniline
Acta Crystallographica Section E, 2011 In the molecule of the title compound, C14H10FN3O, the bicyclic quinazoline system is effectively planar, with a mean deviation from planarity of 0.0140 (3) Å. The quinazoline heterocyclic system and the adjacent benzene ring
Dingqiang Lu, Guibin Wang, Jing Jia
doaj +1 more source