Results 81 to 90 of about 24,434,811 (177)

Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2‑Aminophenyl Ketones and 2‑Aminobenzamides with Amines [PDF]

, 2019
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Chae S. Yi, Pandula T. Kirinde Arachchige, Arachchige, Pandula T. Kirinde, Pandula T. Kirinde Arachchige (5136719), Yi, Chae S., Chae S. Yi (1540366)   +5 more
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Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Molecules
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra   +7 more
doaj   +1 more source

Synthesis of 3-[2-(1H-imidazol-2-yl)alkyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018
Promising biologically active substances are derivatives of imidazole and quinazoline, which are part of the structure of known antifungal drugs and substances with anti-TB and antimicrobial activity.
O. A. Zavada, O. V. Tkachenko, I. O. Zhuravel   +2 more
doaj   +1 more source

The preparation and reactivity of some potassium Purine-, Quinazoline-, and Tetrahydroquinazoline-sulphonates

, 1972
The potassium salts of purine-6(and 8)-, 9-methylpurine-6-, quinazoline-2(and 4)-, 5,6,7,8-tetrahydroquinazoline-4-, and 5,6,7,8- tetrahydro-2-methylquinazoline-4-sulphonic acid are prepared by treatment of the corresponding thiones with aqueous ...
DJ Brown, JA Hoskins
core   +1 more source

Synthesis of Quinazoline Derivatives

Efficient synthesis of heterocyclic has always been a very important task in drug discovery. Most of the drugs contain heterocycles to provide an interface between chemistry and biology.
Yadav, Anjali, Kumari, Akriti, Kaur, Navjeet, Devi, Meenu, Dwivedi, Jaya, Kumar, Ashish   +5 more
core   +1 more source

2,5-Dimethyl-6,7-dihydrobenzo[h]-pyrazolo[1,5-a]quinazoline and 2-tert-butyl-5-methyl-6,7-dihydrobenzo[h]-pyrazolo[1,5-a]quinazoline

, 2007
In both 2,5- dimethyl- 6,7- dihydrobenzo[ h] pyrazolo[ 1,5- a]quinazoline, C16H15N3, ( I), and 2- tert- butyl- 5- methyl- 6,7dihydrobenzo[ h] pyrazolo[ 1,5- a] quinazoline, C19H21N3, ( II), which crystallizes with Z' = 2 in the space group P1, the ...
Portilla, Jaime, Cobo, Justo, Low, John N., Quiroga, Jairo, Glidewell, Christopher   +4 more
core   +1 more source

Structure-based rational design and biological evaluation of a quinazoline-based EGFR exon 20 insertion inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry
This study describes the structure-based design and synthesis of potent quinazoline-based inhibitors targeting EGFR exon 20 insertion (exon20ins) mutants, one of the challenging oncogenic drivers in non-small cell lung cancer (NSCLC). Guided by in silico
Sooheum Jo, Hyunsoo Jang, Suin Kim, Jaebong Jang   +3 more
doaj   +1 more source

6-(2-Fluorophenyl)-5,6-dihydrobenzimidazolo[1,2-c]quinazoline

Acta Crystallographica Section E, 2008
In the title compound, C20H14FN3, the pyrimidine ring adopts a half-chair conformation. The dihedral angle between the benzimidazole ring system and the fluorophenyl ring is 84.18 (10)°.
Ai-Ke Li, Jian-Xin Chen, Li-Qun Zheng, Mei-Ping Zhu, Li Zhang   +4 more
doaj   +1 more source

Synthesis of 6-acrylamido-4-(2-[18F]fluoroanilino)quinazoline: Aprospective irreversible EGFR binding probe [PDF]

, 2004
Acrylamido-quinazolines substituted at the 6-position bindirreversibly to the intracellular ATP binding domain of the epidermalgrowth factor receptor (EGFR).
Nandanan,Erathodiyil, Gibbs, Andrew R., O'Neil, James P., Dorff, Peter N., Vasdev, Neil, VanBrocklin, Henry F., Nandanan, Erathodiyil, Reid, Leanne M.   +7 more
core  

Quinazoline derivatives: synthesis and bioactivities

, 2013
Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations ...
Wang, Dan, Feng Gao, Gao, Feng, Dan Wang
core   +1 more source