Results 1 to 10 of about 17,703,275 (296)

The Emerging Regulation of VEGFR-2 in Triple-Negative Breast Cancer [PDF]

Frontiers in Endocrinology, 2015
Vascular endothelial growth factor-A (VEGF) signals vascular development and angiogenesis mainly by binding to VEGF receptor family member 2 (VEGFR-2). Adaptor proteins mediate many VEGFR-2’s functions in the development of blood vessels.
Xiaoxia eZhu, Wen eZhou
exaly   +5 more sources

EXPRESSION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS (VEGFR-1 AND VEGFR-2) IN PRIMARY TUMOR CELLS IN PATIENTS WITH RENAL CANCER

Сибирский онкологический журнал, 2021
Purpose: to study the expression of vascular endothelial growth factor (vegf-a) and its receptors (vegfr-1 and vegfr-2) in renal cell carcinoma (rcc) cells and assess the effect of the expression levels of these markers on the tumor characteristics and ...
D. A. Khochenkov, M. I. Volkova, I. V. Timofeev, A. S. Olshanskaya, Yu. A. Khochenkova, E. Sh. Solomko, S. A. Ashuba, V. B. Matveev   +7 more
doaj   +1 more source

PRMT4-mediated arginine methylation promotes tyrosine phosphorylation of VEGFR-2 and regulates filopodia protrusions

iScience, 2022
Summary: Through tightly controlled multilayer mechanisms, vascular endothelial growth factor receptor-2 (VEGFR-2) activation and its downstream signal transduction govern vasculogenesis and pathological angiogenesis, such as tumor angiogenesis ...
Edward Hartsough, Rajani R.J. Shelke, Razie Amraei, Zahra Aryan, Saran Lotfollahzadeh, Nader Rahimi   +5 more
doaj   +1 more source

VEGFER-2 INHIBITORS AND QUINAZOLINE-BASED ANTICANCER AGENTS [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2023
Inhibitors of vascular endothelial growth factor receptor -2 (VEGFR-2) are crucial biological targets for the development of novel anticancer medications.
Helmy Sakr, Islam Otify, Rezk Ayyad, Alaa Elwan   +3 more
doaj   +1 more source

Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor receptor 2 (VEGFR-2), the primary receptor for VEGF, is crucial for normal endothelial function. sFlt-1, a truncated and soluble form of VEGFR-1 which binds and inhibits VEGF, is increased in preeclampsia and is ...
Ori Nevo, Dennis K Lee, Isabella Caniggia   +2 more
doaj   +1 more source

Establishment of an oral squamous cell carcinoma cell line expressing vascular endothelial growth factor a and its two receptors

Journal of Dental Sciences, 2022
Background/purpose: Vascular endothelial growth factor receptor (VEGFR) expression in oral squamous cell carcinoma (OSCC) promotes tumor growth through both autocrine and paracrine signaling.
Hanako Araki-Maeda, Mutsuki Kawabe, Yuji Omori, Koji Yamanegi, Kazunari Yoshida, Kyohei Yoshikawa, Kazuki Takaoka, Kazuma Noguchi, Yoshiro Nakano, Hiromitsu Kishimoto   +9 more
doaj   +1 more source

VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance

Gastrointestinal Disorders, 2020
Background: Angiogenesis plays an important role in colorectal cancer (CRC) tumorigenesis and metastatic progression. Methods: The present series consisted of CRC lymph node metastasis (LNM) tissue samples from 210 patients.
Inês Mazeda, Sandra F. Martins, Eduardo A. Garcia, Mesquita Rodrigues, Adhemar Longatto   +4 more
doaj   +1 more source

Silencing VEGFR-2 Hampers Odontoblastic Differentiation of Dental Pulp Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Dental pulp stem cells (DPSCs) are a source of postnatal stem cells essential for maintenance and regeneration of dentin and pulp tissues. Previous in vivo transplantation studies have shown that DPSCs are able to give rise to odontoblast-like cells ...
Kajohnkiart Janebodin, Kajohnkiart Janebodin, Kajohnkiart Janebodin, Rakchanok Chavanachat, Aislinn Hays, Aislinn Hays, Aislinn Hays, Morayma Reyes Gil   +7 more
doaj   +1 more source

IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. [PDF]

PLoS ONE, 2008
Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer and age-related macular degeneration.
Rosana D Meyer, David B Sacks, Nader Rahimi   +2 more
doaj   +1 more source

Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role

Frontiers in Cell and Developmental Biology, 2020
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in many physiological and pathological processes, and is involved in endothelial ...
Xinrong Wang, Alfredo Maria Bove, Giuseppe Simone, Binyun Ma   +3 more
doaj   +1 more source