Results 31 to 40 of about 24,477,013 (226)

VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment

International Journal of Inflammation, 2015
Glioblastoma multiforme (GBM) is one of the most angiogenic tumors. However, antiangiogenic therapy has not shown significant clinical efficacy. The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of ...
Jana Jaal, Marju Kase, Ave Minajeva, Mikk Saretok, Aidi Adamson, Jelizaveta Junninen, Tõnis Metsaots, Tõnu Jõgi, Madis Joonsalu, Markus Vardja, Toomas Asser   +10 more
doaj   +1 more source

Altered expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, and Soluble Fms-like Tyrosine Kinase-1 in peripheral blood mononuclear cells from normal and preeclamptic pregnancies

Chinese Journal of Physiology, 2019
Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality. It complicates around 2%–10% pregnancies worldwide due to imbalance between proangiogenic and anti-angiogenic factors, leading to incomplete placentation, ischemia, and
Zaima Ali, Saba Khaliq, Saima Zaki, Hafiz Usman Ahmad, Khalid Pervaiz Lone   +4 more
doaj   +1 more source

Elucidating activation and deactivation dynamics of VEGFR-2 transmembrane domain with coarse-grained molecular dynamics simulations

PLoS ONE, 2023
The vascular endothelial growth factor receptor 2 (VEGFR-2) is a member of receptor tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary regulator of angiogenesis.
Yeon Ju Go, Mahroof Kalathingal, Young Min Rhee   +2 more
doaj   +2 more sources

Differential expression of Vegfr-2 and its soluble form in preeclampsia.

PLoS ONE, 2012
BackgroundSeveral studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably, soluble sVEGFR-1 (also known as sFlt-1) and soluble ...
Carine Munaut, Sophie Lorquet, Christel Pequeux, Capucine Coulon, Jeanne Le Goarant, Frédéric Chantraine, Agnès Noël, Frédéric Goffin, Vassilis Tsatsaris, Damien Subtil, Jean-Michel Foidart   +10 more
doaj   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Molecular Docking Approach of Some Quinoxaline Derivatives as Anticancer Agents Targeting VEGFR-2. [PDF]

Alfarama Journal of Basic & Applied Sciences
The vascular endothelial growth factor receptor-2 (VEGFR-2) has a crucial role in the angiogenesis of cancer. The growth of tumors was effectively prevented by inhibiting the VEGFR-2 regulatory pathway.
Lamiaa Barakat, Mohamed Tawfik, Mayada Elsakka, Mohamed Nafie   +3 more
doaj   +1 more source

Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation

Scientific Reports, 2023
Multitarget anticancer drugs are more superior than single target drugs regarding patient compliance, drug adverse effects, drug-drug interactions, drug resistance as well as pharmaceutical industry economics.
Abdelfattah Hassan, Ahmed M. Mosallam, Amal O. A. Ibrahim, Mohamed Badr, Aboubakr H. Abdelmonsef   +4 more
doaj   +1 more source

Lv-vegfr-10-Ig expression during BC transfating.

, 2019
(A) Control gastrula. Lv-vegfr-10-Ig is expressed at high levels by PMCs (arrow), as previously reported [9]. (B) PMC(−) embryo, 2 hpd. Expression of Lv-vegfr-10-Ig is evident in the invaginating vegetal plate (arrow), a region that includes presumptive ...
Ashrifia Adomako-Ankomah (7401002), Charles A. Ettensohn (5062514)   +1 more
core   +1 more source

The Effects of VEGF Signal Pathway on Etiopathogenesis and AntiVEGF Treatments in Childhood Cancers

Çocuk Dergisi, 2023
Vascular endothelial growth factor (VEGF) is the most physiologically and pathologically potent angiogenic factor that acts directly on endothelial cells.
Ali Kazdal, Meryem Ertuğrul, Selma Söylemez, Hikmet Gülşah Tanyıldız   +3 more
doaj   +1 more source

Lv-VEGFR-10-Ig is required for BC transfating.

, 2019
(A) MO knockdown strategy. Following the approach of Duloquin and coworkers [9], an MO was directed at the exon 2/intron 2 splice junction of the Lv-vegfr-10-Ig primary transcript. (B) RT-PCR analysis of morphant embryos. The Lv-vegfr-10-Ig MO produced a
Ashrifia Adomako-Ankomah (7401002), Charles A. Ettensohn (5062514)   +1 more
core   +1 more source