Results 41 to 50 of about 17,703,275 (296)

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate, Plate, Karl, Wittko-Schneider, Ina M., Schneider, Fabian T., Fabian T. Schneider, Ina M. Wittko-Schneider   +5 more
core   +1 more source

Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors [PDF]

Molecules, 2016
In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2. Highly potent VEGFR-2 inhibitors 1 and 3 were caged by introduction of a photoremovable protecting group (PPG) to yield the caged prodrugs 4 and 5.
Boris Pinchuk, Rebecca Horbert, Alexander Döbber, Lydia Kuhl, Christian Peifer   +4 more
openaire   +3 more sources

Generation and characterization of a human nanobody against VEGFR-2 [PDF]

Acta Pharmacologica Sinica, 2016
Nanobody is an antibody fragment consisting of a single monomeric variable antibody domain, which can be used for a variety of biotechnological and therapeutic purposes. The aim of this work was to isolate and characterize a human signal domain antibody against VEGFR-2 domain3 (VEGFR D3) from a phage display library.To produce antigen-specific ...
Lin, Ma, Kai, Gu, Cheng-Hai, Zhang, Xue-Tao, Chen, Yi, Jiang, Karsten, Melcher, Juan, Zhang, Min, Wang, H Eric, Xu   +8 more
openaire   +2 more sources

Elucidating activation and deactivation dynamics of VEGFR-2 transmembrane domain with coarse-grained molecular dynamics simulations

PLoS ONE, 2023
The vascular endothelial growth factor receptor 2 (VEGFR-2) is a member of receptor tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary regulator of angiogenesis.
Yeon Ju Go, Mahroof Kalathingal, Young Min Rhee   +2 more
doaj   +2 more sources

VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment

International Journal of Inflammation, 2015
Glioblastoma multiforme (GBM) is one of the most angiogenic tumors. However, antiangiogenic therapy has not shown significant clinical efficacy. The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of ...
Jana Jaal, Marju Kase, Ave Minajeva, Mikk Saretok, Aidi Adamson, Jelizaveta Junninen, Tõnis Metsaots, Tõnu Jõgi, Madis Joonsalu, Markus Vardja, Toomas Asser   +10 more
doaj   +1 more source

Altered expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, and Soluble Fms-like Tyrosine Kinase-1 in peripheral blood mononuclear cells from normal and preeclamptic pregnancies

Chinese Journal of Physiology, 2019
Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality. It complicates around 2%–10% pregnancies worldwide due to imbalance between proangiogenic and anti-angiogenic factors, leading to incomplete placentation, ischemia, and
Zaima Ali, Saba Khaliq, Saima Zaki, Hafiz Usman Ahmad, Khalid Pervaiz Lone   +4 more
doaj   +1 more source

VEGFR-2: One of Pioglitazone's Signaling Pathways in the Heart

Arquivos Brasileiros de Cardiologia, 2018
Departamento de Clinica Medica Faculdade de Medicina de Botucatu Universidade Estadual Paulista Julio de Mesquista Filho ...
Minicucci, Marcos Ferreira, Zornoff, Leonardo Antonio Mamede   +1 more
openaire   +4 more sources

The Effects of VEGF Signal Pathway on Etiopathogenesis and AntiVEGF Treatments in Childhood Cancers

Çocuk Dergisi, 2023
Vascular endothelial growth factor (VEGF) is the most physiologically and pathologically potent angiogenic factor that acts directly on endothelial cells.
Ali Kazdal, Meryem Ertuğrul, Selma Söylemez, Hikmet Gülşah Tanyıldız   +3 more
doaj   +1 more source

Molecular Docking Approach of Some Quinoxaline Derivatives as Anticancer Agents Targeting VEGFR-2. [PDF]

Alfarama Journal of Basic & Applied Sciences
The vascular endothelial growth factor receptor-2 (VEGFR-2) has a crucial role in the angiogenesis of cancer. The growth of tumors was effectively prevented by inhibiting the VEGFR-2 regulatory pathway.
Lamiaa Barakat, Mohamed Tawfik, Mayada Elsakka, Mohamed Nafie   +3 more
doaj   +1 more source

Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation

Scientific Reports, 2023
Multitarget anticancer drugs are more superior than single target drugs regarding patient compliance, drug adverse effects, drug-drug interactions, drug resistance as well as pharmaceutical industry economics.
Abdelfattah Hassan, Ahmed M. Mosallam, Amal O. A. Ibrahim, Mohamed Badr, Aboubakr H. Abdelmonsef   +4 more
doaj   +1 more source