Results 21 to 30 of about 24,477,013 (226)

Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study

Journal of Family Medicine and Primary Care, 2020
Background: Macular drusen formation and angiogenesis are the two chief processes associated with age-related macular degeneration. Adropin and vascular endothelial growth factor receptor-2 (VEGFR-2) may be involved in these pathologies.
Areekulangara Neethu, Kuppuswami Jayashree, Gandhipuram Periyasamy Senthilkumar, K Ramesh Babu, Mehalingam Vadivelan   +4 more
doaj   +1 more source

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source

Biomechanical stimulation promotes blood vessel growth despite VEGFR-2 inhibition

BMC Biology, 2023
Background Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor ...
Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry, Mary Kathryn Sewell-Loftin   +6 more
doaj   +1 more source

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

Molecules, 2022
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric essential features to bind correctly with the VEGFR-2 active pocket.
Eslam B. Elkaeed, Reda G. Yousef, Mohamed M. Khalifa, Albaraa Ibrahim, Ahmed B. M. Mehany, Ibraheem M. M. Gobaara, Bshra A. Alsfouk, Wagdy M. Eldehna, Ahmed M. Metwaly, Ibrahim H. Eissa, Mohamed Ayman El-Zahabi   +10 more
doaj   +1 more source

Additional file 3 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 3: Figure S2. Hypersensitivity-induced by VEGF-A family members is not due to the interaction with VEGFR-2. The response to a thermal stimulus (Cold plate test) was recorded after intrathecal infusion (30 ng) of (a) VEGF165b (n=5), (b ...
Lorenzo Di Cesare Mannelli (600627), Sabatino Maione (140730), Pedro Miguel Lacal (11567064), Carla Ghelardini (600626), Paola Failli (443253), Alessia Vona (11567061), Flavia Ricciardi (6590378), Alessandra Pacini (748841), Elena Lucarini (5326928), Serena Boccella (331854), Carmen Parisio (9395492), Grazia Graziani (111563), Laura Micheli (256012), Tommaso Mello (677155), Alessandra Toti (9395495)   +14 more
core   +1 more source

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate, Plate, Karl, Wittko-Schneider, Ina M., Schneider, Fabian T., Fabian T. Schneider, Ina M. Wittko-Schneider   +5 more
core   +1 more source

Additional file 7 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 7: Figure S6. VEGFR-2 is increased in the spinal cord of mice with oxaliplatin-induced neuropathy. Representative western blot images and densitometric analysis of VEGF-R1 and VEGFR-2 expression in the lumbar section of the spinal cord of
Lorenzo Di Cesare Mannelli (600627), Sabatino Maione (140730), Pedro Miguel Lacal (11567064), Carla Ghelardini (600626), Paola Failli (443253), Alessia Vona (11567061), Flavia Ricciardi (6590378), Alessandra Pacini (748841), Elena Lucarini (5326928), Serena Boccella (331854), Carmen Parisio (9395492), Grazia Graziani (111563), Laura Micheli (256012), Tommaso Mello (677155), Alessandra Toti (9395495)   +14 more
core   +1 more source

The Emerging Regulation of VEGFR-2 in Triple Negative Breast Cancer

Frontiers in Endocrinology, 2015
Vascular endothelial growth factor-A (VEGF) signals vascular development and angiogenesis mainly by binding to VEGF receptor family member 2 (VEGFR-2). Adaptor proteins mediate many VEGFR-2’s functions in the development of blood vessels.
Xiaoxia eZhu, Wen eZhou
doaj   +1 more source

Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer

Cells, 2022
NSCLC treatment includes targeting of EGFR with tyrosine kinase inhibitors (TKIs) such as Erlotinib; however, resistance to TKIs is commonly acquired through T790M EGFR mutations or overexpression of vascular endothelial growth factor receptor-2 (VEGFR-2)
Chike Osude, Leo Lin, Meet Patel, Adam Eckburg, Joseph Berei, Adijan Kuckovic, Namrata Dube, Aayush Rastogi, Shruti Gautam, Thomas J. Smith, Shylendra B. Sreenivassappa, Neelu Puri   +11 more
doaj   +1 more source

Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity [PDF]

, 2017
Vascular endothelial growth factor (VEGF) signaling is tightly regulated by specific VEGF receptors (VEGF-R). Recently, we identified heterodimerisation between VEGFR-1 and VEGFR-2 (VEGFR1–2) to regulate VEGFR-2 function.
Gu, Yuchun, Cai, Meng, Murdoch, Colin E., Murdoch, Colin E.; id_orcid, Wang, Keqing, Ahmed, Asif   +5 more
core   +1 more source