Results 21 to 30 of about 17,703,275 (296)

CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis [PDF]

Blood, 2012
AbstractCD146 is a novel endothelial biomarker and plays an essential role in angiogenesis; however, its role in the molecular mechanism underlying angiogenesis remains poorly understood. In the present study, we show that CD146 interacts directly with VEGFR-2 on endothelial cells and at the molecular level and identify the structural basis of CD146 ...
Tianxia, Jiang, Jie, Zhuang, Hongxia, Duan, Yongting, Luo, Qiqun, Zeng, Kelong, Fan, Huiwen, Yan, Di, Lu, Zhongde, Ye, Junfeng, Hao, Jing, Feng, Dongling, Yang, Xiyun, Yan   +12 more
openaire   +2 more sources

Soluble VEGFR‐2: an antilymphangiogenic variant of VEGF receptors [PDF]

Annals of the New York Academy of Sciences, 2010
The vascular endothelial growth factor (VEGF) family of secreted proteins and their receptors are major regulators of blood vessel development (hemangiogenesis) and lymphatic vessel development (lymphangiogenesis). VEGF acts through a complex system of receptor tyrosine kinases, which can be membrane bound or soluble.
Pavlakovic, Helena, Becker, Jürgen, Albuquerque, Romulo, Wilting, Jörg, Ambati, Jayakrishna   +4 more
openaire   +3 more sources

VEGFR-2 in Endothelial Differentiation and Vascular Organization

, 2008
The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. During embryogenesis, endothelial progenitor cells (angioblasts) are recruited from the primitive streak mesoderm and instructed to ...
Edholm, Dan
openaire   +2 more sources

VEGFR-2 blockade induces tumor T cell infiltration.

, 2022
MC38 tumor bearing mice were treated with 40mg/kg Rat IgG, MF1 (anti-VEGFR-1), DC101 (anti-VEGFR-2) and mF4-31C1 (VEGFR-3) at a single dose, and then tumors were collected on day 14.
Thompson N. Doman (12263590), Ruslan Novosiadly (5156267), Yanxia Li (436765), Erik R. Rasmussen (13113500), Michael Kalos (5156288), Manisha Brahmachary (67743), Bronislaw Pytowski (13113503), Ivan Inigo (2698249), Nelusha Amaladas (13113491), Marguerita O’Mahony (13113494), Gerald Hall (5156303), David A. Schaer (13113506), Oscar Puig (155433), Qi Li (67548), Jason R. Manro (13113497)   +14 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour propagation.
Mohammed M. Alanazi, Ibrahim H. Eissa, Nawaf A. Alsaif, Ahmad J. Obaidullah, Wael A. Alanazi, Abdullah F. Alasmari, Hussam Albassam, Hazem Elkady, Alaa Elwan   +8 more
doaj   +1 more source

Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma. [PDF]

PLoS ONE, 2013
BACKGROUND: Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC. We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC. METHODS:
Chao Li, Jinchuan Fan, Xicheng Song, Bing Zhang, Yu Chen, Chunhua Li, Kun Mi, Hong Ma, Yufeng Song, Xiaofeng Tao, Guojun Li   +10 more
doaj   +1 more source

Accumulation of VEGFR-2+/CD133+ cells and decreased number and impaired functionality of CD34+/VEGFR-2+ cells in patients with SLE [PDF]

Rheumatology, 2009
Inflammation and atherosclerosis are the major causes of cardiovascular disease (CVD) in SLE. Both traditional and disease-specific risk factors contribute to the formation of endothelial dysfunction. Endothelial progenitor cells (EPCs) have the ability to restore endothelial integrity.
Petra, Ebner, Frauke, Picard, Jutta, Richter, Eleonore, Darrelmann, Matthias, Schneider, Bodo-Eckehard, Strauer, Michael, Brehm   +6 more
openaire   +2 more sources

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source