Results 51 to 60 of about 24,434,811 (177)

Synthesis and characterization of some new 4-heteroaryl quinazoline and fused triazolo quinazoline derivatives

, 2016
Treatment of chloroquinazoline (2) with primary amines (2-aminothiazoles and sulpha drugs) and secondary amines (morpholine, piperidine, and piperazine) furnished 4-substituted aminoquinazolines (3a,b and 4a,b), 4-aryl quinazolines (5a,b), and ...
El-Badry, Yaser Abdel-Moemen, El-Hashash, Mahr Abdel-Aziz, Nassar, Ekhlass   +2 more
core   +1 more source

Electron-Withdrawing Substituted Quinazoline Push-Pull Chromophores: Synthesis, Electrochemical, Photophysical and Second-Order Nonlinear Optical Properties [PDF]

, 2020
International audienceA series of chromophores bearing 4-cyanoquinazoline, 2-(4-cyanophenyl)quinazoline or 2-(4-trifluorophenyl)quinazoline electron-acceptor (A) and 5-(4-aminophenyl)thiophen-2-yl or 4-aminophenyl electron-donor (D) units has been ...
Nosova, E. V., Lipunova, Galina N, Moshkina, T. N., Lipunova, Galina N., Moshkina, Tatiana N, Bure?, F., Le, Poul, P., Emiliya V. Nosova, Moshkina, Tatiana N., Lipunova, G. N., Achelle, S., Robin-Le, Guen, F., Charushin, V. N., Nosova, Emiliya V., Oldřich Pytela, Sylvain Achelle, Charushin, Valery N., Pytela, O., Françoise Robin‐Le Guen, Galina N. Lipunova, Barsella, A., Pascal Le Poul, Le Poul, Pascal, Pytela, Oldřich, Tatiana N. Moshkina, Alberto Barsella, Valery N. Charushin, Charushin, Valery N, Barsella, Alberto, Nosova, Emiliya V, Robin-Le Guen, Françoise, Achelle, Sylvain, Filip Bureš, Bureš, Filip   +33 more
core   +1 more source

Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate

Acta Crystallographica Section E, 2013
In the title compound, C29H23ClN4O4, the quinazoline-indole system and the indolin-2-one system are each essentially planar, with maximum deviations from their mean planes of 0.150 (2) and 0.072 (2) Å, respectively.
Piskala Subburaman Kannan, Srinu Lanka, Sathiah Thennarasu, E. Govindan, Arunachalathevar SubbiahPandi   +4 more
doaj   +1 more source

Radical‐Mediated 1,2‐Boryl Migration: An Emerging Strategy Toward Diverse Boronate Molecules and Polymers

Transformative Chemistry, EarlyView.
This perspective highlights radical‐mediated 1,2‐boryl migration as a thermodynamically driven radical translocation strategy that enables the construction of diverse functionalized organoboronates, the transposition editing of organic molecules, and the synthesis of C3 alternating copolymers.
Chaoran Xu, Xiangcheng Pan
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Quinazoline derivative compound (11d) as a novel angiogenesis inhibitor inhibiting VEGFR2 and blocking VEGFR2-mediated Akt/mTOR /p70s6k signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d.
Zeng Li, Bin Wang, Liang Tang, Shuangsheng Chen, Jun Li   +4 more
doaj  

3-(4-Chlorophenyl)quinazolin-4(3H)-one

Acta Crystallographica Section E, 2011
In the title compound, C14H9ClN2O, the quinazoline unit is essentially planar, with a mean deviation from the least-squares plane defined by the ten constituent ring atoms of 0.027 (2) Å.
M. Gnana Ruba Priya, T. Srinivasan, K. Girija, N. Ravi Chandran, D. Velmurugan   +4 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Drugs acting on CNS: Syntheses of 2-substituted & 2,3-disubstituted benzo( 6,7) quinazoline-4 -ones [PDF]

, 1968
A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the reaction of 2-ethylthio-benzo(6,7)
Gupta, C. M., Bhaduri, A. P., Khanna, K. M.   +2 more
core   +1 more source

A Review of Quinazoline-Based EGFR/VEGFR-2 Dual Inhibitors as Potent Anticancer Agents: Structure-Activity Relationship and Docking Studies [PDF]

Pharmaceutical Sciences
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that initiates various signaling pathways resulting in processes such as gene expression, proliferation, angiogenesis, and inhibition of apoptosis.
Fatemeh Yousefbeyk, Saeed Ghasemi
doaj   +1 more source