Results 21 to 30 of about 24,434,811 (177)

Dipolar Cycloaddition Reactions with Quinazolinones: A New Route for the Synthesis of Several Annelated Pyrrolo- and Pyridazinoquinazoline Derivatives

Molecules, 2003
The novel 2-aryl-3a,4,12,12a-tetrahydropyrrolo[3',4':4,3]-pyridazino[6,1-b]-quinazoline-1,3,6-triones (6a–d), 2-aryl-10-oxopyridazino[6,1-b]-quinazoline-3-thio-carboxamides (10a–d) and 2-aryl-3-nitro-1,2,3,4-tetrahydro-pyridazino[6,1-b ...
Hatem M. Gaber, Sami S. Ghabrial
doaj   +1 more source

Synthesis of potent antileukemic quinazoline-thiohydantoin fused heterocycles enabled by metal-free domino reaction [PDF]

, 2023
Heterocyclic compounds play a central role in drug development research and are contained in most pharmaceuticals on the market. Quinazoline and thiohydantoin are heterocycles and hold very prominent positions due to their diverse pharmacological ...
Svetlana B., Tsogoeva, Sanjay V. , Malhotra, Arpit , Dheeraj, Ean-Jeong , Seo, Lars, Herrmann, Mohamed E.M. , Saeed, Thomas , Efferth, Christoph, Zippel, Susanne , Muehlich, Dhanir , Tailor, Lena, Kersting, Angelika , Gaube   +11 more
core   +2 more sources

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

Angewandte Chemie, EarlyView.
The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch, Yitzhak Tor, Claudia Höbartner   +2 more
wiley   +2 more sources

3'-R-Spiro[cycloalkyl-1(2), (hetaryl-3(4), 6'-[1,2,4]triazino[2,3-c]quinazoline]-2'(7'H)-2-оnes as a perspective class of compounds with actoprotective activity

Zaporožskij Medicinskij Žurnal, 2017
Quinazolines and their derivatives are a perspective class of compounds with versatile biological activities. Their representatives are used in medical practice as sleeping, diuretic, antimicrobial and antitumor drugs.
O. S. Kolomoets, О. Yu. Voskoboynik, I. S. Nosulenko, O. V. Krivoshey, A. I. Avramenko, G. G. Berest, S. I. Kovalenko   +6 more
doaj   +1 more source

Syntheses of Quinazoline-2,4-dione Alkaloids and Analogues from Mexican Zanthoxylum Species â€

Molecules, 2004
Quinazolinone and quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. In this paper we report the synthesis of ten quinazolinediones.
R. Somanathan, K. Espinoza, I. A. Rivero
doaj   +1 more source

Actoprotective activity of 6-monosubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino-[2,3-c]quinazoline-2-ones

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Aim. Currently drugs with actoprotective activity are increasingly applied in sport medicine, military medicine, space medicine, emergence medicine, deep-see medicine rehabilitative medicine during high physical stresses.
O. S. Kolomoets, I. S. Nosulenko, О. Yu. Voskoboynik, G. G. Berest, S. I. Kovalenko, S. D. Trzhetsinsky   +5 more
doaj   +1 more source

STUDY OF THE STABILITY OF THE SUBSTANCE 3-[2-(4-PHENYL-1-PIPERAZINO)-2-OXOETHYL]QUINAZOLINE-4(3Н)-ONE UNDER STRESSFUL CONDITIONS

Фармация и фармакология (Пятигорск), 2021
The aim of the research was to study the stability of a new pharmaceutical substance 3-[2-(4-phenyl-1-piperazino)-2-oxoethyl]quinazoline-4(3Н)-one under stress conditions.Materials and methods.
T. A. Gendugov, A. A. Glushko, A. A. Ozerov, L. I. Shcherbakova   +3 more
doaj   +1 more source

Study of the Anti-klebsiella Activity of Quinazoline Compounds Containing a Piperazine Ring

Антибиотики и Химиотерапия
The aim of this study was to investigate the antimicrobial activity of piperazine ring-containing quinazoline compounds against Klebsiella pneumoniae.
A. A. Tsibizova, A. L. Yasenyavskaya, G. N. Genatullina, A. A. Ozerov, M. A. Samotrueva   +4 more
doaj   +1 more source

Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

Journal of Saudi Chemical Society, 2011
A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles,
Ahmed M. Alafeefy, Adel S. El-Azab, Menshawy A. Mohamed, Mohamed Afroz Bakhat, S. G. Abdel-Hamid   +4 more
doaj   +1 more source

Evaluation of hepatotoxic properties of pyrimidine derivatives

Сибирский научный медицинский журнал, 2022
The aim of the study was to evaluate the hepatotoxic properties of new pyrimidine derivatives 3-[2-(1-naphthyl)-2- oxoethyl]-6-bromoquinazoline-4(3H)-oh (VMA–13–06), 3-(2-tert-butyl-2-oxoethyl)quinazoline-4(3H)-one (VMA-13- 11) and 3-(2-isopropyloxy-2 ...
A. L. Yasenyavskaya, A. A. Tsibizova, A. A. Ozerov, I. N. Tyurenkov   +3 more
doaj   +1 more source