Results 71 to 80 of about 1,403,395 (345)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Genetic Variants Associated with Hypertension Risk: Progress and Implications

Pulse
Background: Genetic variants causing diseases with hypertension as a secondary feature have previously been identified. Studies focussing on primary hypertension have utilised common and latterly rare genetic variants in attempts to elucidate the genetic
David Curtis
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fat embolism and COVID-19 infection: autopsy and post-mortem laboratory findings in SARS-CoV-2 positive patients

Biomedical Papers
Introduction. The article is one of the very first autopsy reports worldwide, which associates COVID-19 infection and pulmonary fat embolism. Aims. To point to a crucial connection between a severe acute respiratory syndrome caused by coronavirus 2 (SARS-
Adriana Gavronova, Lukas Hamerlik, Margita Bartkova, Vaclav Svrchokryl, Veronika Kralikova, Katerina Vranova, Peter Ondra, Martin Dobias   +7 more
doaj   +1 more source

Enhanced immobilization of U(VI) using a new type of FeS-modified Fe0 core-shell particles

Chemical Engineering Journal, 2019
Sulfur-modified zero valent iron (S-ZVI) particles have been reported to show improved reactivity and selectivity than conventional ZVI. However, current methods for ZVI sulfidation do not fully utilize the advantages of the material, and S-ZVI has not ...
Jun Duan, Haodong Ji, Wen Liu, Xiao Zhao, Bing Han, Shuting Tian, Dongye Zhao   +6 more
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Intelligent modelling and control with fatigue reduction for fes induced knee joint of hemiplegic for rehabilitation [PDF]

, 2017
Functional electrical stimulation (FES) is one of the treatment for the people with stroke such as hemiplegic body (half body paralysed) by applying small charges of electricity to the muscle to induce the movement.
Mohamed Nasir, Noorhamizah
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Generación de híbridos de maíz de Valles Altos de México y su empleo en microempresas de semillas.

Agronomía Mesoamericana, 2016
Con la nueva Ley de Semillas, el Tratado de Libre Comercio puesto en Marcha en enero de 1994, así como el precio elevado de la semilla de híbridos y la gran área potencial de uso de semilla mejorada de maíz.
Alejandro Espinosa, Margarita Tadeo, Angel Piña del Valle, Rafael Martínez   +3 more
doaj   +3 more sources

Madura foot: How MRI aids in diagnosis

Radiology Case Reports
A 46-year-old farmer living in a rural area, who sustained an injury to his left foot 10 years ago, consulted due to progressive swelling of the same foot. An MRI revealed the “dot-in-circle” sign, suggestive of mycetoma of the foot, also known as Madura
Amina Hamdaoui, Assia Benchekroun, Kaoutar Maasaoui, Hicham Elbtioui, Amal Akammar, Nizar El Bouardi, Mariam Haloua, Moulay Youssef Lamrani, Mariam Boubbou, Mustapha Maaroufi, Badr Alami   +10 more
doaj   +1 more source