Results 101 to 110 of about 1,507,917 (263)

Prevalence of erythrocyte alloimmunization in polytransfused patients [PDF]

Einstein (São Paulo), 2011
Objective: To determine the incidence and the rate of red blood cellalloimmunization in polytransfused patients. Methods: A polytransfusedpatient was defined as having received at least 6 units of red cellconcentrates during a 3-month period. The records
Roberto de Oliveira Cruz, Mariza Aparecida Mota, Fabiana Mendes Conti, Ricardo Antônio d’Almeida Pereira, Jose Mauro Kutner, Maria Giselda Aravechia, Lilian Castilho   +6 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Editorial – Potential risks of the SARS-related coronavirus 2 infection [COVID-19] in pregnancy [PDF]

CellR4, 2020
A. Sfakianaki, C. Colon, C. Ndubizu, A. Mohamed, M. Paidas, J. Potter   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A study to assess correlation between maternal weight gain and fetal outcome among primigravidae registered in antenatal clinics

Journal of Family Medicine and Primary Care, 2019
Context: Inadequate prenatal weight gain is a significant risk factor for adverse maternal and fetal outcomes. Nutrient intake and weight gain during pregnancy are the two main modifiable factors influencing maternal and infant outcomes.
Swati T Dahake, Uzma A Shaikh
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen [PDF]

, 2002
The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus.
Wilcox, Nick, Matthews, I, Stott, David, Ledwidge, S, Vincent, Angela, Willcox, N, Beeson, David, Vincent, A, Sims, G, Stott, D, Matthews, Ian, Sims, Gary, Ledwidge, Serena, Beeson, D   +13 more
core   +1 more source

Editorial: Women in developmental and reproductive toxicology: 2021

Frontiers in Toxicology, 2022
Jennifer J. Adibi, Sofie Christiansen, Suzanne E. Fenton, Alison Holloway, Heather B. Patisaul   +4 more
doaj   +1 more source

Effect of Fetal Sex on Maternal and Obstetric Outcomes

Frontiers in Pediatrics, 2017
Fetal sex plays an important role in modifying the course and complications related to pregnancy and may also have an impact on maternal health and well-being both during and after pregnancy.
Mohammed Al-Qaraghouli, Yu Ming Victor Fang   +1 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source