Results 91 to 100 of about 1,402,786 (318)

Interrelation of aromatase, estrogen receptor alpha and progesterone receptor in the developing mouse fetal brain

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2013
Purpose: Aromatase (Cyp19a1) is crucial for the sexually dimorphic development of the fetal brain, regulation of gonadotropin secretion and sexual interest in adults.
Mehmet Bertan Yilmaz, Mehmet Ali Erkoc, Sabriye Kocaturk-Sel, Erdal Tunc, Lutfiye Ozpak, Ayfer Pazarbasi, Ali Irfan Guzel, Davut Alptekin, Husnu Umit Luleyap, Osman Demirhan, Mulkiye Kasap, Halil Kasap   +11 more
doaj  

Using the Optical Fractionator to Estimate Total Cell Numbers in the Normal and Abnormal Developing Human Forebrain

Frontiers in Neuroanatomy, 2017
Human fetal brain development is a complex process which is vulnerable to disruption at many stages. Although histogenesis is well-documented, only a few studies have quantified cell numbers across normal human fetal brain growth. Due to the present lack
Karen B. Larsen, Karen B. Larsen
doaj   +1 more source

Fetal-to-fetal kidney transplantation in utero

Communications Biology
Abstract Potter sequence consists of various symptoms associated with renal dysplasia. For bilateral renal agenesis, there is no hope of survival. As a novel therapeutic approach for Potter sequence, we develop a unique approach of “transplantation of fetal kidneys from a different species during the fetal stage.” In this study, we ...
Keita Morimoto, Shuichiro Yamanaka, Kenji Matsui, Yoshitaka Kinoshita, Yuka Inage, Shutaro Yamamoto, Nagisa Koda, Naoto Matsumoto, Yatsumu Saito, Tsuyoshi Takamura, Toshinari Fujimoto, Shohei Fukunaga, Susumu Tajiri, Kei Matsumoto, Katsusuke Ozawa, Seiji Wada, Eiji Kobayashi, Takashi Yokoo   +17 more
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Dilemmas in fetal medicine: premature application of technology or responding to womens choice?

, 2006
Copyright @ 2006 The Author.It is argued that innovative health technologies (IHTs) may be changing the roles of both patients and health practitioners, and raising new issues, including ethical, legal and social dilemmas.
Williams, C, Clare Williams
core   +1 more source

Environmental Justice Index and adverse pregnancy outcomesAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: The Environmental Justice Index is a tool released by the Centers for Disease Control and Prevention that quantifies and ranks the environmental burden and social vulnerability of each census tract.
Jaclyn Del Pozzo, DO, Insaf Kouba, MD, Alejandro Alvarez, MPH, Tadhg O'Sullivan-Bakshi, Kaveri Krishnamoorthy, Matthew J. Blitz, MD, MBA   +5 more
doaj   +1 more source

Ontogeny of innate T lymphocytes - some innate lymphocytes are more innate then others

Frontiers in Immunology, 2014
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is innate in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and
David eVermijlen, Immo ePrinz
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Fetal Therapies and Maternal-Fetal Tolerance [PDF]

, 2016
The ability to diagnose and treat genetic diseases before birth represents one of the foremost breakthroughs of modern medicine. While fetal surgery has advanced in the last several decades, the prospect of applying developments in stem cell biology and ...
MacKenzie, Tippi, Tippi MacKenzie, Graca Almeida-Porada, Porada, Graca Almeida   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source