Results 81 to 90 of about 1,402,786 (318)

ST analysis of fetal electrocardiography in labor

, 2011
Since its introduction more than 40 years ago, electronic fetal monitoring has become widely used for intrapartum surveillance to determine fetal wellbeing in labor.
I. Amer-Wåhlin, K. Maršál, Marsal, K, Amer-Wåhlin, Isis, Marsal, Karel, Amer-Wahlin, I   +5 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fetal alcohol syndrome; guidelines for referral and diagnosis [PDF]

National Center on Birth Defects and Developmental Disabilities in coordination with National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect (American Academy of Pediatrics, American College of Obstetricians and Gynecologists, March of ...

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Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Small size, big problems: insights and difficulties in prenatal diagnosis of fetal microcephaly

Frontiers in Neuroscience
Microcephaly is a sign, not a diagnosis. Its incidence varies widely due to the differences in the definition and the population being studied. It is strongly related to neurodevelopmental disorders.
Leila Haddad, Leila Haddad, Leila Haddad, Efrat Hadi, Efrat Hadi, Efrat Hadi, Zvi Leibovitz, Zvi Leibovitz, Dorit Lev, Dorit Lev, Dorit Lev, Yoseph Shalev, Yoseph Shalev, Liat Gindes, Liat Gindes, Liat Gindes, Tally Lerman-Sagie, Tally Lerman-Sagie, Tally Lerman-Sagie   +18 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fetal alcohol spectrum disorders: strategies to address information gaps [PDF]

, 2014
Fetal Alcohol Spectrum Disorders (FASD) is emerging as a public health issue in Australia. Health-care providers and policy makers need accurate and timely data in a useable format to monitor and prevent FASD.

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International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy.

, 2014
OBJECTIVES: There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations.
Villar, J, L J Salomon, J Villar, Victora, C. G., Victora, CG, Noble, J. A., Papageorghiou, A. T., Ismail, L. Cheikh, Cheikh Ismail, L, Noble, JA, Kennedy, S. H., E O Ohuma, Ohuma, Eric, R Pang † †, Jaffer, YA, A T Papageorghiou, Dr A Papageorghiou, Altman, DG, Gravett, M. G., Z A Bhutta, Pang, R., Lambert, Ann, J A Noble, Bhutta, ZA, S H Kennedy, Salomon, L. J., Pang, R, Villar, J., M Carvalho, L Cheikh Ismail, Bertino, E., Carvalho, M., Gravett, MG, Altman, D. G., Purwar, M., Bertino, E, C G Victora ¶, #z A B, Kennedy, Stephen, Y A Jaffer, Carvalho, M, E Bertino, International Fetal and Newborn Growth Consortium for the 21st C, Villar, Jose, § § §#, Barros, FC, J, A Lambert, M Purwar ¶ ¶, Kennedy, SH, Papageorghiou, Aris, D G Altman, Lambert, A., Altman, Doug, Ohuma, E. O., M G Gravett § §, Jaffer, Y. A., Salomon, LJ, Lambert, A, F C Barros § ¶, Purwar, M, Carvalho, Maria, Ohuma, EO, Bhutta, Z. A., Papageorghiou, AT, Barros, F. C.   +65 more
core   +1 more source