Results 81 to 90 of about 1,507,917 (263)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Fetal alcohol spectrum disorders: strategies to address information gaps [PDF]

, 2014
Fetal Alcohol Spectrum Disorders (FASD) is emerging as a public health issue in Australia. Health-care providers and policy makers need accurate and timely data in a useable format to monitor and prevent FASD.

core  

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]

, 2002
Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Bergman, A., Berg, J.J.J., van den, van den Berg, J.H.J., Meerts, I.A.T.M., Weijers, B.M., van den Berg, J.J.J., Brouwer, A., Assink, Y., Cenijn, P.H., Berg, J.H.J. van den, Koeman, J.H., Assin, Y.   +11 more
core   +2 more sources

Interrelation of aromatase, estrogen receptor alpha and progesterone receptor in the developing mouse fetal brain

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2013
Purpose: Aromatase (Cyp19a1) is crucial for the sexually dimorphic development of the fetal brain, regulation of gonadotropin secretion and sexual interest in adults.
Mehmet Bertan Yilmaz, Mehmet Ali Erkoc, Sabriye Kocaturk-Sel, Erdal Tunc, Lutfiye Ozpak, Ayfer Pazarbasi, Ali Irfan Guzel, Davut Alptekin, Husnu Umit Luleyap, Osman Demirhan, Mulkiye Kasap, Halil Kasap   +11 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In utero exposure to di(n-butyl) phthalate and testicular dysgenesis:comparison of fetal and adult end points and their dose sensitivity [PDF]

, 2007
BACKGROUND: Fetal exposure of male rats to di(n-butyl) phthalate (DBP) induces reproductive disorders similar to those in human testicular dysgenesis syndrome (TDS), including infertility, cryptorchidism, focal "dysgenetic areas," and Sertoli cell-only ...
Mahood, I. Kim, Scott, Hayley M., Hayley M. Scott, Richard M. Sharpe, I. Kim Mahood, Nina Hallmark, Walker, Marion, Sharpe, Richard M., Hallmark, Nina, Richard Brown, Brown, Richard, Marion Walker   +11 more
core   +1 more source

Environmental Justice Index and adverse pregnancy outcomesAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: The Environmental Justice Index is a tool released by the Centers for Disease Control and Prevention that quantifies and ranks the environmental burden and social vulnerability of each census tract.
Jaclyn Del Pozzo, DO, Insaf Kouba, MD, Alejandro Alvarez, MPH, Tadhg O'Sullivan-Bakshi, Kaveri Krishnamoorthy, Matthew J. Blitz, MD, MBA   +5 more
doaj   +1 more source

Prenatal diagnosis of congenitally corrected transposition of the great arteries

Journal of Ultrasonography, 2019
Congenitally corrected transposition of the great arteries is a rare and complex congenital heart disease. It essentially occurs with atrioventricular and ventriculoarterial discordance, in which the great vessels become parallel.
Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Edward Araujo Júnior   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source