Results 181 to 190 of about 2,983,769 (289)

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Media portrayals of alcohol use in pregnancy and fetal alcohol spectrum disorder: A scoping review. [PDF]

Alcohol Clin Exp Res (Hoboken)
Robards FJ, Medlow S, Elliott EJ.
europepmc   +1 more source

Developmental stuttering with common and complex phenotypes

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1460-1475, October 2026.
Abstract Aim To describe the phenotypic spectrum associated with stuttering. Method Individuals with current or resolved developmental stuttering self‐referred. Surveys assessed stuttering characteristics (onset, negative impact, family history) and health (early development, other conditions).
Sarah E. Horton, Daisy A. Shepherd, Stephanie Siemers, Miya St John, Juliette Catherall, Ingrid E. Scheffer, Angela T. Morgan   +6 more
wiley   +1 more source

Involvement in daily life activities from the perspectives of children and young people with childhood‐onset disabilities: A scoping review

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1351-1364, October 2026.
This scoping review aimed to understand the construct ‘involvement’ in daily life activities from the perspective of children and young people with childhood‐onset disabilities. We identified six conceptual ideas, including a continuum of inner dedication or investment in‐the‐moment, and five others reflecting how children and young people process ...
Vera C Kaelin, Kinga Quaaden, Helena Lindgren, Mats Granlund, Christine Imms   +4 more
wiley   +1 more source

The Gut-Brain Axis in Fetal Alcohol Spectrum Disorder (FASD): Why the Gut Shapes Behavior, Depression, and Self-Injurious Behavior in Children with Prenatal Alcohol Exposure-A Narrative Review with a Proposal for Staged Nutritional and Microbiological Intervention. [PDF]

J Clin Med
Zych-Krekora K, Sylwestrzak O, Krekora M.   +2 more
europepmc   +1 more source

Associations between prenatal alcohol exposure and parent‐reported sleep disturbances in 10,336 adolescents: an Adolescent Brain Cognitive Development study

Journal of Child Psychology and Psychiatry, Volume 67, Issue 10, Page 1680-1691, October 2026.
Background This study investigated the associations between prenatal alcohol exposure (PAE), including low and moderate levels of exposure, and parent‐reported sleep disturbances during adolescence. This is an area that remains understudied despite evidence linking PAE, particularly heavy PAE, to poor sleep in younger children and the growing ...
Emma K. Devine, ReJoyce Green, Rachel Visontay, Hollie Byrne, Julia Riches, Elizabeth J. Elliott, Nicola C. Newton, Lindsay M. Squeglia, Louise Mewton, Lexine A. Stapinski   +9 more
wiley   +1 more source

Fetal Alcohol Spectrum Disorder: The Caring and Financial Burden to Caregivers-A Scoping Review. [PDF]

Drug Alcohol Rev
Tait J, Gibbs A, McCormack J, Wilson H, Chu JTW.   +4 more
europepmc   +1 more source

N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A series of extended aromatic compounds with tunable substituents was synthesized using a multistep methodology which allows various substitutions of the 8H‐quino[4,3,2‐kl]acridine scaffold. This chemical series appeared as a promising way to new antimalarial drug candidates with high activity (IC50 < 100 nM), exhibiting a novel mechanism of action ...
Steve Saulnier, Marco Antônio G. B. Gomes, Mariam Salim, Maxime Guichonnet, Michel Nguyen, Laure Vendier, Flore Nardella, Jean‐Michel Augereau, Dennis Gomez, Anne Robert, Françoise Benoit‐Vical   +10 more
wiley   +1 more source

Establishing the prevalence of fetal alcohol spectrum disorder among young people in Youth Justice residences in Aotearoa, New Zealand: a study protocol. [PDF]

BMJ Open
Chu JTW, McCormack JC, McGinn V, Bullen C, Gibbs A, Seaford A, Ware Ngāpuhi F, Mutch R, Jones H, Umali E, Gardiner C, Wilson H, Moki H, Fai'ai A, Parag V, Newcombe D.   +15 more
europepmc   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, Volume 15, Issue 33, 4 September 2026.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source