Results 171 to 180 of about 3,196,136 (280)

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

From teratogens to trajectories: Integrating teratology and Developmental Origins of Health and Disease (DOHaD) frameworks for a new take on fetal alcohol spectrum disorders (FASD). [PDF]

Neurobiol Stress
Weinberg J, Moritz K.
europepmc   +1 more source

Developmental stuttering with common and complex phenotypes

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1460-1475, October 2026.
Abstract Aim To describe the phenotypic spectrum associated with stuttering. Method Individuals with current or resolved developmental stuttering self‐referred. Surveys assessed stuttering characteristics (onset, negative impact, family history) and health (early development, other conditions).
Sarah E. Horton, Daisy A. Shepherd, Stephanie Siemers, Miya St John, Juliette Catherall, Ingrid E. Scheffer, Angela T. Morgan   +6 more
wiley   +1 more source

Prevention of Fetal Alcohol Spectrum Disorders in Primary Care: Use of Office Champions Model to Address Alcohol Use. [PDF]

Ann Fam Med
Bharati R, Wood J, Haidar AA, Villareal A, Senthilkumar H, Gazewood JD, Quinlan JD, Udezi V.   +7 more
europepmc   +1 more source

Involvement in daily life activities from the perspectives of children and young people with childhood‐onset disabilities: A scoping review

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1351-1364, October 2026.
This scoping review aimed to understand the construct ‘involvement’ in daily life activities from the perspective of children and young people with childhood‐onset disabilities. We identified six conceptual ideas, including a continuum of inner dedication or investment in‐the‐moment, and five others reflecting how children and young people process ...
Vera C Kaelin, Kinga Quaaden, Helena Lindgren, Mats Granlund, Christine Imms   +4 more
wiley   +1 more source

Regional cerebellum volume anomalies and associated cognitive function in children with fetal alcohol spectrum disorders. [PDF]

Alcohol Clin Exp Res (Hoboken)
Gimbel BA, Roediger DJ, Tuominen KA, Anthony ME, Doughty AL, Ernst AM, Mueller BA, de Water E, CIFASD, Wozniak JR.   +9 more
europepmc   +1 more source

Associations between prenatal alcohol exposure and parent‐reported sleep disturbances in 10,336 adolescents: an Adolescent Brain Cognitive Development study

Journal of Child Psychology and Psychiatry, Volume 67, Issue 10, Page 1680-1691, October 2026.
Background This study investigated the associations between prenatal alcohol exposure (PAE), including low and moderate levels of exposure, and parent‐reported sleep disturbances during adolescence. This is an area that remains understudied despite evidence linking PAE, particularly heavy PAE, to poor sleep in younger children and the growing ...
Emma K. Devine, ReJoyce Green, Rachel Visontay, Hollie Byrne, Julia Riches, Elizabeth J. Elliott, Nicola C. Newton, Lindsay M. Squeglia, Louise Mewton, Lexine A. Stapinski   +9 more
wiley   +1 more source

Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders? [PDF]

Alcohol Clin Exp Res (Hoboken)
May PA, Hasken JM, Blankenship J, Marais AS, Gossage JP, Kalberg WO, De Vries M, Robinson LK, Buckley D, Manning M, Parry CDH, Hoyme HE, Tabachnick B, Seedat S.   +13 more
europepmc   +1 more source

N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A series of extended aromatic compounds with tunable substituents was synthesized using a multistep methodology which allows various substitutions of the 8H‐quino[4,3,2‐kl]acridine scaffold. This chemical series appeared as a promising way to new antimalarial drug candidates with high activity (IC50 < 100 nM), exhibiting a novel mechanism of action ...
Steve Saulnier, Marco Antônio G. B. Gomes, Mariam Salim, Maxime Guichonnet, Michel Nguyen, Laure Vendier, Flore Nardella, Jean‐Michel Augereau, Dennis Gomez, Anne Robert, Françoise Benoit‐Vical   +10 more
wiley   +1 more source

Feasibility trial of the My Health Coach app for adults with fetal alcohol spectrum disorders. [PDF]

Res Dev Disabil
Speybroeck EL, Petrenko C, Tapparello C, Romanos C, Griffin K, Hargrove E, Himmelreich M, Lutke A, Lutke CJ, May M, Kautz-Turnbull C, Rockhold MN, Myers J.   +12 more
europepmc   +1 more source