Results 211 to 220 of about 2,021,787 (280)

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort

Clinical Endocrinology, Volume 105, Issue 3, Page 307-313, September 2026.
ABSTRACT Background Polyendocrine metabolic ovarian syndrome (PMOS) and gestational diabetes mellitus (GDM) independently influence foetal growth, but their combined impact remains poorly characterised. This study examined the individual and joint associations of PMOS and GDM with neonatal anthropometry in a large, multi‐ethnic population.
Harshal A. Deshmukh, Amal Rauf, Eunice Waife, Aatif Syed, Emmanuel Ssemmondo, Najeeb Shah, Thozhukat Sathyapalan   +6 more
wiley   +1 more source

Stunting, underweight and thinness in internationally adopted children: prevalence and associated factors in a large cohort study. [PDF]

Eur J Pediatr
Monti N, Kulak M, Lisi C, Rakevich Y, Manca M, Venturini E, Bianchi L, Galli L, Chiappini E.   +8 more
europepmc   +1 more source

The Stigmatization of Caregivers of Children With Attention‐Deficit/Hyperactivity Disorder: A Systematic Review

Family Process, Volume 65, Issue 3, September 2026.
ABSTRACT Research on Attention‐Deficit/Hyperactivity Disorder (ADHD)‐related stigma has centered on individuals with the diagnosis. Evidence concerning caregivers exists but has not been brought together in a way that clarifies its scope, correlates, and implications, despite caregivers' central role in navigating services, supporting daily functioning,
Samuel Guerin, Jeffrey McCrossin, Romuald Blanc, Émilie Cappe   +3 more
wiley   +1 more source

Re‐evaluation of salt of aspartame‐acesulfame (E 962) as food additive

EFSA Journal, Volume 24, Issue 9, September 2026.
Abstract The present opinion deals with the re‐evaluation of salt of aspartame‐acesulfame (E 962) as a food additive. The Panel considered that upon ingestion, E 962 dissociates into aspartame and acesulfame ions which correspond to those of the authorised sweeteners aspartame (E 951) and acesulfame K (E 950). The Panel therefore assessed the safety of
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Ellen Bruzell, Cristina Fortes, Kevin James Chipman, Riccardo Crebelli, Peter Fürst, Jean‐Charles Leblanc, Evangelia Ntzani, Andrea Terron, Matthew Wright, Stefania Barmaz, Costanza Bonnici, Consuelo Civitella, Elena Mazzoli, Josef Daniel Rasinger, Ana Rincon, Camilla Smeraldi, Alexandra Tard, Federica Lodi   +34 more
wiley   +1 more source

Collaborative knowledge mobilisation to increase awareness and use of new SNOMED clinical terms for fetal alcohol spectrum disorder in England. [PDF]

Front Public Health
Parsonage JTI, Dillon A, Millington L, Mukherjee RAS, Butcher SI, Boyd A, Jackson PD, McQuire C.   +7 more
europepmc   +1 more source

Increased Prevalence of Rare Copy Number Variants in Australian Children With Fetal Alcohol Spectrum Disorder: Experience in a State-Wide Diagnostic Service. [PDF]

Alcohol Clin Exp Res (Hoboken)
Byrnes S, Collins F, Elliott E.
europepmc   +1 more source