Results 51 to 60 of about 1,720 (143)

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, Volume 40, Issue 5, Page 2710-2729, May 2026.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Selected Abstracts of the 13th International Workshop on Neonatology; Cagliari (Italy); October 25th-28th, 2017

Journal of Pediatric and Neonatal Individualized Medicine, 2017
Selected Abstracts of the 13th International Workshop on Neonatology • The power of Epigenetics • Twins: identical but different • Cagliari (Italy) • October 25th-28th, 2017 ABS 1. NEONATAL ACUTE KIDNEY INJURY AND OXI­DATIVE STRESS • A.
--- Various Authors
doaj   +1 more source

A Scoping Review of Non‐Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle, Oliver M. Lowden, Rhea E. Sullivan, Taryn E. McFadden, Jennifer E. Nyland   +4 more
wiley   +1 more source

Post‐marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1128-1147, May 2026.
Abstract Objective Calcitonin gene‐related peptide (CGRP) inhibitors, including monoclonal antibodies (mAbs) and small‐molecule antagonists (gepants), have transformed migraine treatment. Although clinical trials established their efficacy and initial safety, post‐marketing surveillance is essential for understanding their real‐world safety profile in ...
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Comparison of blood pressure measurements between the Huawei Watch D smartwatch application and the validated Omron M3 Intellisense device: Observational study

Experimental Physiology, Volume 111, Issue 4, Page 1746-1755, 1 April 2026.
Abstract Popular wearable devices that record a variety of health metrics, such as real‐time blood pressure (BP), could play a role in detecting hypertension in the population. The objective of this study was to compare the validity of the Huawei D device with that of the Omron M3 Intellisense device used by health workers.
Jorge Velázquez Saornil, Raúl Frutos Llanes, Sonia Jiménez Blanco, Zacarías Sánchez Milá, José Manuel Barragán Casas, Rosario Pastor Martín, Angélica Campón Chekroun, David Rodríguez Sanz   +7 more
wiley   +1 more source

Fetal Atrial Flutter and Hydrops Successfully Treated with Transplacental and Direct Fetal Therapy

Prenatal Cardiology, 2016
Abstract The hydropic fetus with atrial flutter has high risk of fetal demise. In utero treatment is not as successful as SVT with 1:1 conduction. Even after conversion to sinus rhythm, close follow-up of the pregnancy is required for several reasons..
openaire   +1 more source

Emergency zero-fluoroscopy catheter ablation for refractory ventricular tachycardia in third-trimester pregnancy: a case report

Frontiers in Cardiovascular Medicine
BackgroundThe incidence of symptomatic arrhythmias during pregnancy has markedly increased in recent years. Atrial fibrillation/flutter and life-threatening ventricular arrhythmias are of particular concern due to their association with elevated maternal
Guiying Liu, Shuping Quan, Xiongbiao Chen, Xianyou Zhang   +3 more
doaj   +1 more source

Poster Session 2

Pregnancy, Volume 2, Issue S2, September 2026.
wiley   +1 more source