Results 61 to 70 of about 486,575 (355)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Learning from child death review in the USA, England, Australia, and New Zealand [PDF]
, 2014 Despite pronounced reductions in child mortality in industrialised countries, variations exist within and between countries. Many child deaths are preventable, and much could be done to further reduce mortality.
Sidebotham, Peter +4 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The clinical predictors of intrauterine fetal death
The Turkish Journal of Pediatrics, 1998 Five hundred and thirteen (513) patients with intrauterine fetal death managed between 1983 and 1990 at Hacettepe University Hospital were analyzed retrospectively. Fetal death rate was 20.5/1,000 deliveries during the study period.
L Onderoğlu, Z S Tuncer
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DOCUMENTATION OF THE FETAL DEATH TAPE FILE FOR 2000 DATA [PDF]
SPECIAL NOTICE: THE GEOGRAPHIC CODES WERE CHANGED EFFECTIVE WITH 1994 DATA TO REFLECT THE RESULTS OF THE 1990 CENSUS.The data is provided to the National Center for Health Statistics (NCHS) through the Vital Statistics Cooperative Program by the ...
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
INCIDENCIA Y FACTORES DE RIESGO ASOCIADOS AL ÓBITO FETAL EN 2 HOSPITALES VENEZOLANOS
Revista Chilena de Obstetricia y Ginecología, 2006 Objetivo: Evaluar la incidencia y factores de riesgo de óbito fetal en una población de embarazadas venezolanas. Metodología: estudio efectuado en 100 mujeres con diagnóstico de óbito fetal que acudieron al servicio de emergencia obstétrica de dos ...
Erika Rojas +3 more
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The challenge of fetal mortality [PDF]
"Data from the Fetal Death Data File and Linked Birth/Infant Death Data Set, National Vital Statistics System. The magnitude of fetal mortality is considerable: About 1 million fetal deaths occur at any gestational age in the United States each year ...
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