Results 81 to 90 of about 486,575 (355)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy.

, 2014
OBJECTIVES: There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations.
Villar, J, L J Salomon, J Villar, Victora, C. G., Victora, CG, Noble, J. A., Papageorghiou, A. T., Ismail, L. Cheikh, Cheikh Ismail, L, Noble, JA, Kennedy, S. H., E O Ohuma, Ohuma, Eric, R Pang † †, Jaffer, YA, A T Papageorghiou, Dr A Papageorghiou, Altman, DG, Gravett, M. G., Z A Bhutta, Pang, R., Lambert, Ann, J A Noble, Bhutta, ZA, S H Kennedy, Salomon, L. J., Pang, R, Villar, J., M Carvalho, L Cheikh Ismail, Bertino, E., Carvalho, M., Gravett, MG, Altman, D. G., Purwar, M., Bertino, E, C G Victora ¶, #z A B, Kennedy, Stephen, Y A Jaffer, Carvalho, M, E Bertino, International Fetal and Newborn Growth Consortium for the 21st C, Villar, Jose, § § §#, Barros, FC, J, A Lambert, M Purwar ¶ ¶, Kennedy, SH, Papageorghiou, Aris, D G Altman, Lambert, A., Altman, Doug, Ohuma, E. O., M G Gravett § §, Jaffer, Y. A., Salomon, LJ, Lambert, A, F C Barros § ¶, Purwar, M, Carvalho, Maria, Ohuma, EO, Bhutta, Z. A., Papageorghiou, AT, Barros, F. C.   +65 more
core   +1 more source

Child death in high-income countries [PDF]

, 2014
Although high income countries have made substantial progress towards reducing child mortality over recent decades, rates vary markedly between and within countries, and modifiable factors continue to be identified in many deaths.
Sidebotham, Peter, Petrou, Stavros, Fraser, J. (James)   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Handbook for death and fetal death registration

, 1989
Revised, January 1989Introduction -- Definitions -- Specific Responsibilities -- General Instructions for Completing the Death and Stillbirth (Fetal Death) Certificates -- Specific Instructions for Completing the Death Certificate -- Specific ...
Kansas Department of Health and Environment
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Cause of fetal death : data from the Fetal Death Report, 2014 [PDF]

Objectives: This report presents, for the first time, data on cause of fetal death by selected characteristics such as maternal age, Hispanic origin and race, fetal sex, period of gestation, and birthweight.Methods: Descriptive tabulations of data ...

core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Comparison of Maternal Anxiety between Primigravid Women and Pregnant Women with the History of Previous Fetal or Neonatal Death

نشریه پرستاری ایران, 2006
Background & Aim: Pregnancy is a significant event for pregnant women who need to adapt physiologically and psychologically, though it is a normal phase of a woman’s life.
M. Ahadi, S. Taavoni, T. Ganji, F. Hosseini   +3 more
doaj