Results 111 to 120 of about 1,396,987 (288)

The effects of unintended pregnancy on maternal bonding impairment among Japanese mothers: a longitudinal study from pregnancy to one month postpartum

BMC Pregnancy and Childbirth
Background Numerous studies have been conducted regarding maternal bonding; however, there is a lack of studies investigating the association with unintended pregnancy.
Hitoshi Kaneko, Yuya Makino, Mami Nakano, Yuichiro Takahashi, Masako Matsui, Kazuyo Ogawa   +5 more
doaj   +1 more source

The position of the testis during the fetal period: an additional parameter to estimate fetal weight

International Brazilian Journal of Urology, 2010
PURPOSE: To establish a correlation between testicular position and fetal weight, in order to provide an additional prenatal parameter for fetal weight estimation. MATERIALS AND METHODS: We studied 288 testes from 144 human fetuses.
Luciano A. Favorito, Waldemar S. Costa, Francisco J. B. Sampaio   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effect of mindfulness group therapy on maternal psychological distress and perinatal outcomes in twin pregnancy: a randomized controlled trial

Frontiers in Psychiatry
PurposePsychosocial stress, depression, and anxiety are prevalent during pregnancy and can be associated with adverse birth outcomes. This study aimed to evaluate the effectiveness of an online Mindfulness Group Therapy (MGT) program in improving ...
Ying Zhou, Zai-Mei Tang, Lin Mei, Xiao-Chang Yang, Hong-Ling Zheng, Bi-Zhen Liao, Xin-Yang Yu   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Preconception underweight impact on postnatal osteoporotic fracture: a retrospective cohort study using Japanese claims data

BMC Pregnancy and Childbirth
Background Undernutrition and underweight are osteoporosis risk factors. Therefore, improving the health of underweight young women in Japan is an important medical issue.
Kayoko Kaneko, Maiko Suto, Eiko Miyagawa, Masashi Mikami, Yukio Nakamura, Atsuko Murashima, Kenji Takehara   +6 more
doaj   +1 more source

Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM

Cell Reports
Summary: Adipose-derived stem cells (ADSCs) represent a promising therapeutic resource, yet their immunometabolic regulation remains poorly defined. Here, we reveal a tunneling nanotube (TNT)-mediated communication mechanism between ADSCs and adipose ...
Bingnan Chen, Xuyang Chen, Jianxin Li, Ruohan Hu, Lijun Yang, Hongli Li, Xinmi Liu, Richard D. Cannon, Richard Saffery, Boris Novakovic, Hongbo Qi, Hua Zhang, Xiaobo Zhou   +12 more
doaj   +1 more source

Antenatal treatment with glucocorticoids and the hypotalamic-pituitary-adrenal axis [PDF]

Journal of Medical Biochemistry, 2014
Fetal development is a critical period in the life cycle which is why the placenta provides a structural and physiological barrier that protects the fetus from the outer fluctuations and inner disturbances.
Manojlović-Stojanoski Milica, Ristić Nataša, Singh Sandra, Milošević Verica   +3 more
doaj