Results 31 to 40 of about 72,689 (257)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Clinical Importance of Serum BDNF (Brain Derived Neurotrophic Factor) Level for the Management of Pregnancies Complicated with Meconium-Stained Amniotic Fluid

Diyala Journal of Medicine
Background: Meconium-stained amniotic fluid complicates pregnancies and is associated with high risk of neonatal meconium aspiration syndrome. Early detection of meconium-stained amniotic fluid is essential to prevent adverse neonatal outcomes ...
Firdaws Midhat Jihad, Esraa Abdulkareem Mohammed   +1 more
doaj   +1 more source

Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy

Life, 2022
Maternal stress can shape long-term child neurodevelopment beginning in utero. One mechanism by which stress is transmitted from mothers to their offspring is via alterations in maternal cortisol, which can cross the placenta and bind to glucocorticoid ...
Cassandra L. Hendrix, Harini Srinivasan, Integra Feliciano, Justin M. Carré, Moriah E. Thomason   +4 more
doaj   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Reliability of Admission Cardiotocography with and without Amniotic Fluid Index in Predicting Maternal and Fetal Outcomes: A Comparative Observational Study

National Board of Examinations Journal of Medical Sciences
Background: Intrapartum fetal problems remain an important cause of illness and death around birth, especially in low-resource settings. Admission CTG is commonly used to quickly check fetal well-being, but its ability to predict problems varies.
K. Mahalakshmi
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Use of Doppler indices in prediction of Acute Fetal Hypoxia – Proposed Staging System [PDF]

Al Ameen Journal of Medical Sciences, 2017
Background: Till now multiple studies regarding Doppler indices in Obstetrics have concentrated on detection of chronic hypoxia, publications have been silent on early detection of fetal hypoxia before the damage sets in.
P.T. Jadhav, Rajani Jadhav, Kartik Jadhav, Thilotama Naidu, J.V. Mundewadi, Nitin Tikare   +5 more
doaj  

Risk factors for neonatal respiratory distress syndrome in severe preeclampsia

Revista Brasileira de Saúde Materno Infantil, 2023
Objectives: to identify predictive factors of respiratory distress syndrome (RDS) in severe preeclampsia. Methods: a cross-sectional study was conducted based on the secondary analysis of a clinical trial about the use of corticosteroids to prevent RDS ...
Melânia M. R. de Amorim, Anibal Faúndes, Luiz Carlos Santos   +2 more
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

In utero defecation: a new concept

The Turkish Journal of Pediatrics, 1998
According to the current concepts, the human fetus does not defecate, and passage of meconium into the amniotic fluid is an indicator of fetal distress.
A O Ciftçi, F C Tanyel
doaj