Results 41 to 50 of about 145,114 (299)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang   +7 more
wiley   +1 more source

Labour pain: the hidden influences of anxiety and social deprivation [PDF]

open access: yes, 2009
No abstract ...
Dolan, J.   +4 more
core  

Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study. [PDF]

open access: yes, 2019
Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk ...
Alexopoulos, Dimitrios   +7 more
core   +2 more sources

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

open access: yesAdvanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang   +10 more
wiley   +1 more source

Accuracy of clinical diagnosis of fetal distress

open access: yesInternational Journal of Medicine and Health Development, 2004
Background: Fetal distress has significantly contributed to the rising caesarean section rate, which is as high as 20-25%. Caesarean section for clinically diagnosed fetal distress has been criticized as being unjustified in many instances.
Joseph I Ikechebelu, Gerald O Udigwe
doaj  

Risk factors for neonatal respiratory distress syndrome in severe preeclampsia

open access: yesRevista Brasileira de Saúde Materno Infantil, 2023
Objectives: to identify predictive factors of respiratory distress syndrome (RDS) in severe preeclampsia. Methods: a cross-sectional study was conducted based on the secondary analysis of a clinical trial about the use of corticosteroids to prevent RDS ...
Melânia M. R. de Amorim   +2 more
doaj   +1 more source

Intra-uterine fetal demise caused by amniotic band syndrome after standard amniocentesis [PDF]

open access: yes, 2000
The amniotic band syndrome represents a prime example of exogenous disruption of an otherwise normal feta I development. It may be a sequel of invasive diagnostic procedures such as amniocentesis or fetal blood sampling. A 38-year-old gravida II, para II
Bauerfeind, I.   +4 more
core   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

open access: yesAdvanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia   +15 more
wiley   +1 more source

Clinical Importance of Serum BDNF (Brain Derived Neurotrophic Factor) Level for the Management of Pregnancies Complicated with Meconium-Stained Amniotic Fluid

open access: yesDiyala Journal of Medicine
Background: Meconium-stained amniotic fluid complicates pregnancies and is associated with high risk of neonatal meconium aspiration syndrome. Early detection of meconium-stained amniotic fluid is essential to prevent adverse neonatal outcomes ...
Firdaws Midhat Jihad   +1 more
doaj   +1 more source

Uterine torsion in the mare: a review and three case reports [PDF]

open access: yes, 2008
When a mare exhibits signs of colic during the last trimester of gestation, uterine torsion should always be part of the differential diagnosis. Uterine torsion is an infrequently occurring but serious complication in pregnant mares.
Chiers, Koen   +7 more
core   +1 more source

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