Results 81 to 90 of about 72,180 (257)

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga   +20 more
wiley   +1 more source

Integrating fetal pulmonary artery doppler with 2D lung volumetry to predict neonatal respiratory distress

open access: yesThe Egyptian Journal of Radiology and Nuclear Medicine
Objectives This study aims to evaluate fetal lung development through volumetric measurements and Doppler assessments of the main pulmonary artery, thereby correlating these findings with neonatal respiratory distress and Apgar score.
Marwa Elsayed Abdelrahman Ibrahim   +3 more
doaj   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

open access: yesBMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing   +6 more
wiley   +1 more source

Homologous membrane wrapped ZIF‐8 nanoparticles accelerate differentiation of neural stem cell for spinal cord injury therapy

open access: yesBMEMat, EarlyView.
Homologous membrane wrapped ZIF‐8 nanoparticles were proposed to improve biocompatibility and targeting ability to neural stem cells (NSCs). ZIF‐8‐SCM NPs exhibit pH responsiveness, thereby generating an intracellular Zn2+ storm to accelerate neural differentiation through calcium and MAPK signaling pathways. Moreover, they promote function recovery in
Jie Wang   +11 more
wiley   +1 more source

Impact of excessive pregnancy weight gain on pregnancy outcomes and neonatal conditions in pre-pregnancy overweight and obese women

open access: yesShanghai yufang yixue
ObjectiveTo explore the influence of excessive weight gain during pregnancy in pre-pregnancy overweight and obese women on pregnancy outcomes and neonatal conditions, and to provide scientific evidence for formulating weight management strategies before ...
CHEN Xia   +4 more
doaj   +1 more source

Humans are not unique: difficult birth is common in placental mammals

open access: yesBiological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Single umbilical artery aneurysm: a rare case report and review of perinatal management

open access: yesJournal of Cardiothoracic Surgery
Background Single umbilical artery aneurysms (SUAA) are extremely rare vascular malformations. Most of the times aneurisms are located in the cors insertion on the placenta, and are associated with increased perinatal morbidity, including fetal growth ...
Qiong Liu   +6 more
doaj   +1 more source

Multifunctional Flexible Thermoelectric Fabric for Smart Wearables

open access: yesCarbon Energy, EarlyView.
This study designs a multifunctional rGO/PEDOT:PSS fabric integrating thermoelectric generation, signal sensing, and EMI shielding. It enables motion detection, respiratory monitoring, and fetal movement tracking. The fabric emphasizes flexibility, durability, comfort, and safety, making it suitable for wearable healthcare applications and advancing ...
Jia Wu   +10 more
wiley   +1 more source

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