Results 41 to 50 of about 263,321 (360)

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

Fetal Diagnosis and Therapy, 2019
Formation of the human heart involves complex biological signals, interactions, specification of myocardial progenitor cells, and heart tube looping.
Cheryl M. J. Tan, A. Lewandowski
semanticscholar   +1 more source

Case Report: Characterization of a Novel NONO Intronic Mutation in a Fetus With X-Linked Syndromic Mental Retardation-34

Frontiers in Genetics, 2020
BackgroundThe NONO gene is located on chromosome Xq13.1 and encodes a nuclear protein involved in RNA synthesis, transcriptional regulation, and DNA repair.
Hairui Sun, Hairui Sun, Hairui Sun, Lu Han, Lu Han, Xiaoshan Zhang, Xiaoyan Hao, Xiaoyan Hao, Xiaoxue Zhou, Xiaoxue Zhou, Ruiqing Pan, Hongjia Zhang, Hongjia Zhang, Yihua He, Yihua He, Yihua He   +15 more
doaj   +1 more source

Fetal heart rate and fetal heart rate variability in Lipizzaner broodmares [PDF]

Acta Veterinaria Hungarica, 2015
Monitoring fetal heart rate (FHR) and fetal heart rate variability (FHRV) helps to understand and evaluate normal and pathological conditions in the foal. The aim of this study was to establish normal heart rate reference values for the ongoing equine pregnancy and to perform a heart rate variability (HRV) time-domain analysis in Lipizzaner mares ...
Baska-Vincze, Boglárka, Baska, Ferenc, Szenci, Ottó   +2 more
openaire   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The reference ranges for fetal ductus venosus flow velocities and calculated waveform indices and their predictive values for right heart diseases

Journal of Perinatal Medicine
This study endeavors to establish comprehensive normal reference ranges and Z score formulas for ductus venosus (DV) flow velocity parameters and calculated waveform indices across different gestational ages in low-risk fetuses.
Wu Jian, Ruan Yanping, Gao Xinru, Wang Hairui, Guan Yuxuan, Hao Xiaoyan, Han Jiancheng, Gu Xiaoyan, He Yihua   +8 more
doaj   +1 more source

Fetal cardiac interventions: clinical and experimental research

Advances in Interventional Cardiology, 2016
Fetal cardiac interventions for congenital heart diseases may alleviate heart dysfunction, prevent them evolving into hypoplastic left heart syndrome, achieve biventricular outcome and improve fetal survival.
Shi-Min Yuan, Gulimila Humuruola
doaj   +1 more source

Prenatally diagnosed fetal heart rhythm abnormalities—incidence, diagnosis and outcome

Clinical and Experimental Obstetrics & Gynecology, 2022
Backrounds: Fetal arrhythmias represent a significant cause of fetal morbidity and mortality and occur in approximately 1–3% of pregnancies. The unknown fetal arrhythmias are the cause of intrauterine fetal demise in as many as 3–10% of cases, as well as
Jelena Stamenković, Vojislav Parezanović, Olivera Kontić-Vučinić, Ivan Stefanović, Maja Trkulja, Ida Jovanović, Aleksandar Ljubić, Milena Srbinović   +7 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Analysis of Genotypes and Phenotypes in Chinese Patients With Tuberous Sclerosis Complex Harboring Novel Variants of TSC1 and TSC2 Genes

International Journal of Genomics
Conclusions: This study broadens the spectrum of variants of TSC1 and TSC2 genes, reaffirming the clinical diagnosis of patients through genetic testing.
Jian Chen, Hairui Sun, Ling Han, Xiaoyan Gu, Xiaoyan Hao, Yuwei Fu, Zongjie Weng, Yi Xiong, Baomin Liu, Hongjia Zhang, Yihua He, Hong Li   +11 more
doaj   +1 more source

Generation of a TSC2 knockout embryonic stem cell line by CRISPR/Cas9 editing

Stem Cell Research
Tuberous Sclerosis Complex (TSC) is a severe developmental disorder with various clinical effects, primarily caused by TSC2 gene mutations, often involving loss of function(Henske,et al., 2016).To explore role of TSC2 in human heart development, we ...
Siyao Zhang, Jiaqi Fan, Hairui Sun, Xiaoyan Hao, Yihua He   +4 more
doaj   +1 more source