Results 41 to 50 of about 469,519 (337)

Early Evaluation of the Fetal Heart [PDF]

Fetal Diagnosis and Therapy, 2017
Evaluation of the fetal heart at 11-13 + 6 weeks of gestation is indicated for women with a family history of congenital heart defects (CHD), a previous child with CDH, or an ultrasound finding associated with cardiac anomalies. The accuracy for early detection of CHD is highly related to the experience of the operator.
Edgar Hernandez-Andrade, Manasi Patwardhan, Mónica Cruz-Lemini, Suchaya Luewan   +3 more
openaire   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Analysis of Genotypes and Phenotypes in Chinese Patients With Tuberous Sclerosis Complex Harboring Novel Variants of TSC1 and TSC2 Genes

International Journal of Genomics
Conclusions: This study broadens the spectrum of variants of TSC1 and TSC2 genes, reaffirming the clinical diagnosis of patients through genetic testing.
Jian Chen, Hairui Sun, Ling Han, Xiaoyan Gu, Xiaoyan Hao, Yuwei Fu, Zongjie Weng, Yi Xiong, Baomin Liu, Hongjia Zhang, Yihua He, Hong Li   +11 more
doaj   +1 more source

Vagal contributions to fetal heart rate variability: an omics approach

, 2019
Fetal heart rate variability (fHRV) is an important indicator of health and disease, yet its physiological origins, neural contributions in particular, are not well understood.
Burns, Patrick, Cao, Mingju, Desrochers, Andre, Durosier, Lucien Daniel, Fecteau, Gilles, Frasch, Martin G., Herry, Christophe L., Seely, Andrew JE   +7 more
core   +1 more source

Evidence-Based Fetal Referrals for Congenital Heart Surgery [PDF]

, 2012
Background. The outcomes of fetal referrals to congenital heart disease centers for delivery and postnatal surgery prior to discharge over a two-year period were reviewed. Cost differences between fetal referrals and neonatal transports were investigated.
Allen, Steven Wayne, Battiste, Cynthia Elaine, O’Hara, Margaret Helen   +2 more
core   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Cascade of Nonlinear Entropy and Statistics to Discriminate Fetal Heart Rates [PDF]

, 2016
International audience—Fetal heart rate discrimination is an evolving field in biomedical engineering with many efforts dedicated to avoid preterm deliveries by way of improving fetus monitoring methods and devices. Entropy analysis is a nonlinear signal
Bouakaz, Ayache, Karameh, Fadi,, Nahas, Ziad, Saleh, Soha, Zaylaa, Amira,   +4 more
core   +2 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

A journey from adult to fetal echocardiography

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging, 2018
As a cardiologist in a group practice or hospital settings, many a times you are requested to comment on fetal Echocardiography performed by radiologist or fetal medicine specialist.
U P Singh, Hargunbir Singh, Ladbans Kaur
doaj   +1 more source

The electrical heart axis of the fetus between 18 and 24 weeks of gestation: A cohort study.

PLoS ONE, 2021
IntroductionA fetal anomaly scan in mid-pregnancy is performed, to check for the presence of congenital anomalies, including congenital heart disease (CHD). Unfortunately, 40% of CHD is still missed. The combined use of ultrasound and electrocardiography
Carlijn Lempersz, Lore Noben, Sally-Ann B Clur, Edwin van den Heuvel, Zhouzhao Zhan, Monique Haak, S Guid Oei, Rik Vullings, Judith O E H van Laar   +8 more
doaj   +1 more source