Results 121 to 130 of about 832,435 (375)

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Blessing in disguise; a case of Hereditary Persistence of Fetal Hemoglobin

Journal of Community Hospital Internal Medicine Perspectives, 2018
Fetal Hemoglobin (HbF, α2γ2) is produced from the eighth week of gestation, constitutes 60 – 80 % of total hemoglobin by birth, which is then replaced with adult Hemoglobin A1 (HbA1: α2β2) by 6–12 months. Hereditary Persistence of Fetal Hemoglobin (HPFH)
Irfan Shaukat, Amrit Paudel, Sayf Yassin, Naseruddin Höti, Sadaf Mustafa   +4 more
doaj   +1 more source

Failure of Microchromatographic Measurement of Fetal Hemoglobin in β0 Thalassemia-Hereditary Persistence of Fetal Hemoglobin

Clinical Chemistry, 1992
Abstract We report microchromatographic measurement of fetal hemoglobin (HbF) proportions in a 36-year-old African-American multigravida woman. At 34 weeks she delivered a 630-g male infant who subsequently did well. Hemoglobin electrophoresis of the hemolysate revealed nearly 100% HbF without HbA, an extremely unusual naturally ...
C. G. Pantazis, Lawrence D. Devoe, M H Jonah, J S Krauss   +3 more
openaire   +3 more sources

Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and Longer Survival in Adults with Sickle Cell Anemia

PLoS ONE, 2015
Background Adults with sickle cell anemia (HbSS) are inconsistently treated with hydroxyurea. Objectives We retrospectively evaluated the effects of elevating fetal hemoglobin with hydroxyurea on organ damage and survival in patients enrolled in our ...
C. Fitzhugh, M. Hsieh, Darlene T Allen, W. Coles, Catherine Seamon, M. Ring, Xiongce Zhao, C. Minniti, G. Rodgers, A. Schechter, J. Tisdale, James G. Taylor   +11 more
semanticscholar   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

Epigenetic modulations on the fetal hemoglobin induction [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2012
In recent years of experience fetal hemoglobin (HbF) induction considers as novel therapeutic approach for β-thalassemia and sickle cell in therapeutic approaches.
Najmaldin Saki, Mehrdad Noruzinia, Saeid Kaviani, Ali Dehghani Fard, Esmaeil Mortaz   +4 more
doaj   +2 more sources

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

The Difference of Hematocrit in Term and Preterm Vaginal Births in Different Timing of Delayed Cord Clampin

Thai Journal of Obstetrics and Gynaecology, 2015
Objective:To compare fetal hematocrit in different timing of delayed cord clamping and fetomaternal outcome at 48 hours after vaginal births.Materials and Methods: 200 term and preterm vaginal births were recruited by inclusion criteria and ...
Somprattana Mungkornkaew, Theera Siwadune   +1 more
doaj   +1 more source

Fabrication and testing of microfluidic devices for blood cell separation [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Desmulliez, MPY, Dhariwal, RS, Kavanagh, DM, Kersaudy-Kerhoas, M, Pavuluri, SK   +5 more
core  

Premarital screening of 466 Mediterranean women for serum ferritin, vitamin B12, and folate concentrations [PDF]

, 2015
Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus.
Demirciler, İ., Güler, Ömer Tolga, Karabulut, Aysun, Karahan, H.T., Koyuncu, H., Özkan, Sevgi   +5 more
core   +1 more source