Results 161 to 170 of about 72,054 (299)

Hereditary Persistence of Fetal Hemoglobin Presenting With 100% Fetal Hemoglobin and Recurrent Thrombotic Events. [PDF]

Cureus
Lachhar GG, Syed S, Abdullah A, Konstantinidis A, Pentheros S, Torres A.   +5 more
europepmc   +1 more source

Pharmacologic Modulation of Fetal Hemoglobin

Medicine, 2001
M H, Steinberg, G P, Rodgers
openaire   +2 more sources

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcription. [PDF]

Redox Biol
Park SW, Choi CY, Park IB, Kang SJ, Lee HJ, Kim JI, Bae J, Geum D, Cheon YP, Chun T.   +9 more
europepmc   +1 more source

Increased calcification by erythrophagocytosis in aortic valvular interstitial cells

ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.
Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin, Magnus Bäck, Anders Franco‐Cereceda, Sven‐Christian Pawelzik   +3 more
wiley   +1 more source

Targeted protein degradation for fetal hemoglobin induction: a new paradigm in β-hemoglobinopathy therapy. [PDF]

Biomark Res
Arji S, Shen Z, Welch S, ElMahdaoui F, Bahadur A, Lee E, Lee H, Wu SP, Konshina E, Ayubali B, Tenen D, Chai L, Liu J.   +12 more
europepmc   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

PGC-1α agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice. [PDF]

Blood Adv
Benmhammed H, Sun Y, AlAbdullatif S, Chen A, Khan S, Zadeh AM, Mazile N, Beacham GM, Mahdaviani K, Williams C, Alekseyev YO, Campbell JD, Hagedorn EJ, Heaphy C, Klings ES, Steinberg MH, Cui S.   +16 more
europepmc   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge. [PDF]

Clin Case Rep
Luo YH, Zuberi N, Rizzolo A, Warner M, Isnard S, Routy JP.   +5 more
europepmc   +1 more source