Results 241 to 250 of about 819,369 (331)

Understanding pre‐eclampsia and fetal growth restriction at high altitude: A narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pre‐eclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of maternal and perinatal morbidity and mortality worldwide. Both conditions are more frequent and severe at high altitudes due to physiological changes in oxygen availability and vascular adaptation.
Víctor S. Rangel, Juliana Malagón Castillo, Juan David Duarte, Mariana Abril Barreto, Alejandra Vivas Ramirez, José Alejandro Daza, Ángela María Ruiz‐Sternberg   +6 more
wiley   +1 more source

Inflammatory Cytokines in Association With High Fetal Hemoglobin Level Reduce the Episodes of Vaso-Occlusive Crisis in Sickle Cell Patients. [PDF]

J Hematol
Dixit S, Das A, Samal P, Sandeepta S, Panigrahi SS, Jain HK, Biswas S, Suar M, Pati S, Ranjit M, Bal M.   +10 more
europepmc   +1 more source

Molecular basis of polycomb group protein-mediated fetal hemoglobin repression.

Blood, 2023
Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine B, Abdulmalik O, Shi J, Hardison RC, Blobel GA.   +10 more
europepmc   +1 more source

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Blood, 2015
Aline Renneville, Peter van Galen, Matthew C. Canver, M. McConkey, J. Krill-Burger, D. Dorfman, E. Holson, B. Bernstein, S. Orkin, D. E. Bauer, B. Ebert   +10 more
semanticscholar   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

Fetal-hemoglobin-expressing red blood cells ("F cells") consist of three distinct types as revealed by single-cell transcriptomic analysis of circulating reticulocytes. [PDF]

Hemasphere
Rooks H, Ng C, Oikonomopoulos S, Hoss SE, Turner C, Kong KL, Mian S, Daniel Y, Ojewunmi OO, Brewin J, Rees D, Mufti GJ, Ragoussis J, Strouboulis J, Menzel S.   +14 more
europepmc   +1 more source

COUP-TFII regulates hemoglobin switching by activating the BCL11A-XL repressor Lin28B and directly binding δ and β globin promoters in fetal versus adult erythroid cells

Carlotta Frigo, Valentina Pastori, Gianluca Zambanini, M. Fabiano, Sajeela Ahmed, Elisabetta Citterio, Claudio Cantù, Antonella Ronchi   +7 more
openalex   +2 more sources

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

, 2011
Jian Xu, Cong Peng, Vijay G. Sankaran, Zhen Shao, Erica B. Esrick, Bryan G. Chong, Gregory C. Ippolito, Yuko Fujiwara, Benjamin L. Ebert, Philip W. Tucker, Stuart H. Orkin   +10 more
openalex   +2 more sources

Effect of Epigallocatechin‐3‐Gallate on Depression‐Related Cytokines in Thalassemia Patients: Molecular and Cellular Evaluation

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigates the effects of Epigallocatechin‐3‐Gallate (EGCG), a potent anti‐inflammatory polyphenol isolated from Winged Marigold, on cytokine expression linked to depression in β‐thalassemia patients. EGCG demonstrated dose‐dependent suppression of key inflammatory cytokines (IL‐6, IL‐1β, TNF‐α, IFN‐γ) at both gene and protein levels ...
Mohammed N. Salman, Fouad Razzaq Al‐Burki, Hazim Ali Hussein, Laith A. Younus, Fadhil A. Nasser, Hasanain A. A. Almohseni   +5 more
wiley   +1 more source

Microcytosis Merits Evaluation: A Case Report of Hemoglobin S With Hereditary Persistence of Fetal Hemoglobin (HbS-HPFH Syndrome). [PDF]

Cureus
Daniel CE, Bejjani A.
europepmc   +1 more source